{"header":{"numFound":34605180,"maxScore":1.0,"queryTime":308,"page":1,"pageSize":10},"results":[{"authors":[{"id":null,"fullName":"Zermeño-Flores, A.I. (Ana Isabel)","name":"A. I.","surname":"Zermeño-Flores","rank":1,"pid":null},{"id":null,"fullName":"Cornelio-Marí, E.M. (Elia Margarita)","name":"E. M.","surname":"Cornelio-Marí","rank":2,"pid":null}],"openAccessColor":null,"publiclyFunded":null,"eoscIfGuidelines":null,"type":"other","language":{"code":"eng","label":"English"},"countries":null,"subjects":[{"subject":{"scheme":"FOS","value":"0508 media and communications"},"provenance":null},{"subject":{"scheme":"FOS","value":"05 social sciences"},"provenance":null}],"mainTitle":"A Multilevel Analysis of the representations of Technology in «Years and Years»","subTitle":null,"descriptions":["The analysis of science fiction narratives is valuable to explore possible futures. This article analyzes the representation of technology in the television series <em>Years and Years</em> (2019), a co-production by the BBC and HBO created by Russell T Davies. This audiovisual narrative depicts key problems of the present in a representation of the near future, enabling the identification of new socio-technological paradigms. We applied the method of Causal Layered Analysis (CLA), a prospective analytical tool used both for the study of diverse current phenomena and for the design of possible futures, which includes the levels of the litany, systemic causes, discourse/world vision, and myth/metaphor. The analysis showed that <em>Years and Years</em> offers a vision of a world in chaos, based on a global capitalist and technological project that threatens fundamental rights, and the existence of the human species. In the series, technologies are imbibed in all the fundamental systems of Western societies, pushing common people into obsolescence. Three narratives uphold the myth of the dominion of science and technology: the technological transcendence of human beings, the irrelevance of humans before technology, and the ubiquitous panopticon of digitized power. Through its bleak version of the future <em>Y&Y</em> puts into focus aspects of technological development that make us reflect critically and urgently about the present."],"publicationDate":"2023-01-01","publisher":"Servicio de Publicaciones de la Universidad de Navarra","embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Repositorio de la Universidad de Navarra"],"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":null,"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"00064aabbda9::0027f5b1dae5e7388c82a3ec88667806","originalIds":["50|00064aabbda9::0027f5b1dae5e7388c82a3ec88667806","oai:navarra.escire.net:10171/65330"],"pids":[{"scheme":"handle","value":"10171/65330"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":0.0,"influence":2.1746283E-9,"popularity":1.6835128E-9,"impulse":0.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"projects":null,"organizations":null,"communities":null,"collectedFrom":[{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}],"instances":[{"pids":[{"scheme":"handle","value":"10171/65330"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Other ORP type","urls":["https://hdl.handle.net/10171/65330"],"publicationDate":"2023-01-01","refereed":"nonPeerReviewed","hostedBy":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"},"collectedFrom":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}}],"links":null,"otherTitles":null,"inDiamondJournal":null,"green":null,"isGreen":null,"isInDiamondJournal":null},{"authors":[{"id":null,"fullName":"Román-Freire, M.J. 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These unique children are known as third culture kids (TCKs). These individuals are spending, or have spent, a significant number of developmental years outside their parent’s cultures(s). Due to their high mobility lifestyles, they experience a series of challenges, such as developing multiple senses of belonging or no sense of belonging. Hence, feelings of being misunderstood by their community are recurrent among them. Generally, TCKs attend international schools, specifically International Baccalaureate Programme (IBP) schools. TCKs have significant academic and socio-personal needs during periods of transition that should be identified by school personnel. Therefore, developing psychoeducational resources to support their adjustment processes is crucial."],"publicationDate":"2023-01-01","publisher":null,"embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Marín-Marín, V. 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The risk of symptomatic RN associated with stereotactic radiosurgery (SRS) as part of the treatment of brain metastases (BMs) has been a subject of recent investigation. The activation of the signal transducer and activator of transcription 3 (STAT3) was shown in reactive astrocytes (RA) associated with BMs. Given that the pathophysiological mechanisms behind RN are not fully understood, we sought to investigate the role of STAT3 among other inflammatory markers in RN development. A mouse model of RN using clinical LINAC-based SRS was designed to induce brain necrosis with the administration of 50 Gy in a single fraction to the left hemisphere using a circular collimator of 5 mm diameter. Immunohis- tochemistry and multiplex staining for CD4, CD8, CD68, GFAP, and STAT3 were performed. For validation, eleven patients with BMs treated with SRS who developed symptomatic RN and required surgery were identified to perform staining for CD68, GFAP, and STAT3. In the mouse model, the RN and perinecrotic areas showed significantly higher staining for F4/80+ and GFAP+ cells, with a high infiltration of CD4 and CD8 T-lymphocytes, when compared to the non-irradiated cerebral hemisphere. A high number of GFAP+pSTAT3+ and F4/80+pSTAT3+ cells was found in the RN areas and the rest of the irradiated hemisphere. The analysis of human brain specimens showed that astrocytes and microglia were actively phosphorylating STAT3 in the areas of RN and gliosis. Phosphorylated STAT3 is highly expressed in the microglia and RA pertaining to the areas of brain RN. Targeting STAT3 via inhibition represents a promising strategy to ameliorate symptomatic RN in BM patients undergoing SRS."],"publicationDate":"2023-01-01","publisher":"MDPI AG","embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Repositorio de la Universidad de Navarra"],"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":null,"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"00064aabbda9::0050b506e44f6cce879f58cab137b114","originalIds":["50|00064aabbda9::0050b506e44f6cce879f58cab137b114","oai:navarra.escire.net:10171/69060"],"pids":[{"scheme":"handle","value":"10171/69060"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":0.0,"influence":2.1746283E-9,"popularity":1.6835128E-9,"impulse":0.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"projects":null,"organizations":null,"communities":null,"collectedFrom":[{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}],"instances":[{"pids":[{"scheme":"handle","value":"10171/69060"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Other ORP type","urls":["https://hdl.handle.net/10171/69060"],"publicationDate":"2023-01-01","refereed":"nonPeerReviewed","hostedBy":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"},"collectedFrom":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}}],"links":null,"otherTitles":null,"inDiamondJournal":null,"green":null,"isGreen":null,"isInDiamondJournal":null},{"authors":[{"id":null,"fullName":"Ainciburu-Fernández, M. 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It has been a broadly studied system since the second half of the 20th century. Attention was drawn to this process after the discovery, in 1951, of the protective role that bone marrow intravenous infusion had against radiation. In the mid-1950s, it was subsequently discovered that this protection was caused by transplanted stem cells contained in the bone marrow. Multipotency of the hematopoietic stem cells (HSCs) was further proven during the 1960s, with the development of clonal in vivo repopulation assays. Following clonal in vitro assays, together with the study of cell surface markers and flow sorting, have configured the current view of the hematopoietic system, as a tree-like hierarchy with the HSCs at the top and mature cells at the bottom (Figure 1.1) [1, 2]. Hematopoiesis is active throughout life and it maintains the pool of mature blood cells, which constitute one of the human tissues with highest turnover. Broadly speaking, specialized blood cells can carry out four main functions: 1) The innate immune system, composed, among others, by macrophages, dendritic cells and granulocytes, constitutes the first defense against infection 2) The adaptive immune system, composed by B and T lymphocytes, carries out a delayed and specialized response against pathogens. 3) Red blood cells transport oxygen to every cell 4) Platelets take care of wound healing."],"publicationDate":"2023-01-31","publisher":"Universidad de Navarra","embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Smerdou, C. (Cristian)","Vanrell, L. 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However, it is considered the most common subtype of endometriosis. The diagnosis of superficial endometriosis remains difficult. In fact, little is known about the ultrasound features of superficial endometriotic lesions. In this study, we aimed to describe the appearance of superficial endometriosis lesions at ultrasound examination, with laparoscopic and/or histologic correlation. This is a prospective study on a series of 52 women with clinical suspicion of pelvic endometriosis who underwent preoperative transvaginal ultrasound and received a confirmed diagnosis of superficial endometriosis via laparoscopy. Women with ultrasound or laparoscopic findings of deep endometriosis were not included. We observed that superficial endometriotic lesions may appear as a solitary lesions, multiple separate lesions, and cluster lesions. The lesions may exhibit the presence of hypoechogenic associated tissue, hyperechoic foci, and/or velamentous (filmy) adhesions. The lesion may be convex, protruding from the peritoneal surface, or it may appear as a concave defect in the peritoneum. Most lesions exhibited several features. We conclude that transvaginal ultrasound may be useful for diagnosing superficial endometriosis, as these lesions may exhibit different ultrasound features."],"publicationDate":"2023-01-01","publisher":null,"embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Repositorio de la Universidad de Navarra"],"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":null,"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"00064aabbda9::0110bf0748730689d67f1106824b7402","originalIds":["oai:navarra.escire.net:10171/67309","50|00064aabbda9::0110bf0748730689d67f1106824b7402"],"pids":[{"scheme":"handle","value":"10171/67309"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":0.0,"influence":2.1746283E-9,"popularity":1.6835128E-9,"impulse":0.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"projects":null,"organizations":null,"communities":null,"collectedFrom":[{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}],"instances":[{"pids":[{"scheme":"handle","value":"10171/67309"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Other ORP type","urls":["https://hdl.handle.net/10171/67309"],"publicationDate":"2023-01-01","refereed":"nonPeerReviewed","hostedBy":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"},"collectedFrom":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}}],"links":null,"otherTitles":null,"inDiamondJournal":null,"green":null,"isGreen":null,"isInDiamondJournal":null},{"authors":[{"id":null,"fullName":"Lemke-Duque, C. 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En primer lugar, se expone el llamado “tipo ideal de hombre español” esbozado entonces. En segundo lugar, se profundiza en la conexión entre esta proyección idealizada y las teorías sociológicas elaboradas en el entramado académico patrocinado por el régimen. El hilo conductor es el diálogo entre políticos, intelectuales y el círculo de la Revista de Occidente. En las conclusiones aflora una transferencia del pensamiento europeo a la cultura española que convirtió a la sociología en instrumento de innovación educativa."],"publicationDate":"2023-01-01","publisher":"Universidad Autónoma de México","embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Repositorio de la Universidad de Navarra"],"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":null,"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"00064aabbda9::0113b5c002b2141d2377d0a8d9d4e972","originalIds":["oai:navarra.escire.net:10171/69077","50|00064aabbda9::0113b5c002b2141d2377d0a8d9d4e972"],"pids":[{"scheme":"handle","value":"10171/69077"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":0.0,"influence":2.1746283E-9,"popularity":1.6835128E-9,"impulse":0.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"projects":null,"organizations":null,"communities":null,"collectedFrom":[{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}],"instances":[{"pids":[{"scheme":"handle","value":"10171/69077"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Other ORP type","urls":["https://hdl.handle.net/10171/69077"],"publicationDate":"2023-01-01","refereed":"nonPeerReviewed","hostedBy":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"},"collectedFrom":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}}],"links":null,"otherTitles":["\"Spanish ideal type”: Socio-pedagogical key of early Francoism"],"inDiamondJournal":null,"green":null,"isGreen":null,"isInDiamondJournal":null},{"authors":[{"id":null,"fullName":"Senén-Guirado, J.A. (José Antonio)","name":"J. A.","surname":"Senén-Guirado","rank":1,"pid":null}],"openAccessColor":null,"publiclyFunded":null,"eoscIfGuidelines":null,"type":"other","language":{"code":"spa","label":"Spanish; Castilian"},"countries":null,"subjects":[{"subject":{"scheme":"keyword","value":"patrimonio arqueológico"},"provenance":null},{"subject":{"scheme":"keyword","value":"restitución"},"provenance":null},{"subject":{"scheme":"FOS","value":"0601 history and archaeology"},"provenance":null},{"subject":{"scheme":"FOS","value":"06 humanities and the arts"},"provenance":null},{"subject":{"scheme":"keyword","value":"expolio"},"provenance":null},{"subject":{"scheme":"keyword","value":"consenso"},"provenance":null}],"mainTitle":"La restitución del patrimonio arqueológico a sus países de origen. Un debate que continúa latente","subTitle":null,"descriptions":["El debate de la restitución y retorno del Patrimonio Arqueológico a sus países de origen sigue siendo a día de hoy un tema que todavía tiene difícil solución, especialmente en cuanto se refiere a las piezas arqueológicas de mayor valor histórico. A pesar de ello, existe un amplio consenso en el seno de la sociedad sobre la necesidad de buscar la mejor solución a dicha cuestión, dando prioridad a la protección patrimonial en todo caso. Analizaremos algunas cuestiones pendientes a día de hoy, así como los casos que más interés han despertado a nivel mediático.","The debate on the restitution and return of the Archaeological Heritage to its countries of origin continues to be today an issue that still has a difficult solution, especially with regard to archaeological objects of greatest historical value. Despite this, there is a broad consensus within society on the need to seek the best solution to this issue, giving priority to heritage protection in any case. We will analyze some pending issues today, as well as the cases that have aroused the most interest at the media level."],"publicationDate":"2023-01-01","publisher":"Servicio de Publicaciones de la Universidad de Navarra","embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Repositorio de la Universidad de Navarra"],"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":null,"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"00064aabbda9::012b847b433735bb1171504ae1edb256","originalIds":["50|00064aabbda9::012b847b433735bb1171504ae1edb256","oai:navarra.escire.net:10171/67646"],"pids":[{"scheme":"handle","value":"10171/67646"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":0.0,"influence":2.1746283E-9,"popularity":1.6835128E-9,"impulse":0.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"projects":null,"organizations":null,"communities":null,"collectedFrom":[{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}],"instances":[{"pids":[{"scheme":"handle","value":"10171/67646"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Other ORP type","urls":["https://hdl.handle.net/10171/67646"],"publicationDate":"2023-01-01","refereed":"nonPeerReviewed","hostedBy":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"},"collectedFrom":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}}],"links":null,"otherTitles":["The restitution of the Archaeological heritage to its countries of origin. A debate still going on"],"inDiamondJournal":null,"green":null,"isGreen":null,"isInDiamondJournal":null},{"authors":[{"id":null,"fullName":"Vilella-Massana, J. (Josep)","name":"J.","surname":"Vilella-Massana","rank":1,"pid":null}],"openAccessColor":null,"publiclyFunded":null,"eoscIfGuidelines":null,"type":"other","language":{"code":"spa","label":"Spanish; Castilian"},"countries":null,"subjects":[{"subject":{"scheme":"keyword","value":"donatismo"},"provenance":null},{"subject":{"scheme":"keyword","value":"Pascua"},"provenance":null},{"subject":{"scheme":"keyword","value":"Osio"},"provenance":null},{"subject":{"scheme":"keyword","value":"concilios"},"provenance":null},{"subject":{"scheme":"keyword","value":"iglesias"},"provenance":null},{"subject":{"scheme":"keyword","value":"credos"},"provenance":null},{"subject":{"scheme":"keyword","value":"Constantino"},"provenance":null},{"subject":{"scheme":"keyword","value":"episcopado"},"provenance":null},{"subject":{"scheme":"keyword","value":"arrianismo"},"provenance":null},{"subject":{"scheme":"keyword","value":"política"},"provenance":null},{"subject":{"scheme":"FOS","value":"06 humanities and the arts"},"provenance":null},{"subject":{"scheme":"FOS","value":"0603 philosophy, ethics and religion"},"provenance":null}],"mainTitle":"De Córdoba a Nicea: Osio en la política eclesiástica constantiniana","subTitle":null,"descriptions":["A partir del estudio analítico-comparativo de un extenso acervo documental que, con frecuencia, plantea complejas cuestiones exegéticas, se valoran y fijan, debidamente contextualizados y hasta la finalización del primer concilio ecuménico, los datos relativos a Osio, obispo de Córdoba. El conocimiento de su decurso vital, estrechamente vinculado con la política constantiniana de intervención uniformadora en los asuntos clericales, permite una mejor y más exacta comprensión de la historia eclesiástica de su época. Tras precisarse su actuación en el cisma donatista, se examinan las relevantes intervenciones que lleva a cabo en el Oriente recién supeditado a Constantino. Insertas, básicamente, en el extenso y poliédrico conflicto arriano, éstas ponen de manifiesto que, desde el principio, Osio toma partido por el obispo alejandrino. Así se colige de su estancia, como comisionado imperial, tanto en Alejandría como en Antioquía, ciudades en las cuales preside sendos sínodos y lleva a cabo otros cometidos: resulta reveladora la redacción, al menos en parte, por Osio de la epístola sinodal antioquena, la cual además evidencia la autoridad que entonces revestía. Respecto al sínodo general, convocado por el regente al constatar la imposibilidad de la reconciliación entre Alejandro y Arrio, se expone su transcurso y la posición encumbrada que en él siguió teniendo el hispano, a pesar de que el presidente de la asamblea fuera Constantino, a quien, sin embargo, substituiría con frecuencia.","Based on the analytic and comparative study of a large documentary collection that frequently raises complex exegetical questions, the information related to Ossius, bishop of Córdoba, is valued, fixed, and duly contextualized until the end of the first oecumenical council. The knowledge of his life, closely linked to the Constantinian policy intending to standardize clerical affairs, allows a better and more accurate understanding of the ecclesiastical history of his time. After specifying his action in the Donatist schism, his relevant interventions carried out in the East, recently subordinated to Constantine, are examined. These interventions, basically inserted in the vast and multifaceted Arian conflict, show that Ossius takes sides with the Alexandrian bishop from the beginning. This one may infer from his stay as imperial commissioner both in Alexandria and Antioch, cities in which he presides over respective synods and accomplish other tasks: it seems revealing the composition (at least partial) by Ossius of the Antiochene synodal letter, which demonstrates the authority he then had. Regarding the general synod summoned by the regent upon verifying the impossible reconciliation between Alexander and Arius, its course and the exalted position that the Hispanic continued to have in it are exposed; and this despite the fact that the president of the assembly was Constantine, whom he would however replace frequently."],"publicationDate":"2023-01-01","publisher":"Servicio de Publicaciones de la Universidad de Navarra","embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Repositorio de la Universidad de Navarra"],"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":null,"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"00064aabbda9::01d5ae5ec0302059a07f4ea5af025794","originalIds":["oai:navarra.escire.net:10171/66925","50|00064aabbda9::01d5ae5ec0302059a07f4ea5af025794"],"pids":[{"scheme":"handle","value":"10171/66925"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":0.0,"influence":2.1746283E-9,"popularity":1.6835128E-9,"impulse":0.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"projects":null,"organizations":null,"communities":null,"collectedFrom":[{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}],"instances":[{"pids":[{"scheme":"handle","value":"10171/66925"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Other ORP type","urls":["https://hdl.handle.net/10171/66925"],"publicationDate":"2023-01-01","refereed":"nonPeerReviewed","hostedBy":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"},"collectedFrom":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}}],"links":null,"otherTitles":["From Córdoba to Nicaea: Ossius in the Constantinian Ecclesiastical Policy"],"inDiamondJournal":null,"green":null,"isGreen":null,"isInDiamondJournal":null},{"authors":[{"id":null,"fullName":"Morelló-Vicente, A. (Ana)","name":"A.","surname":"Morelló-Vicente","rank":1,"pid":null},{"id":null,"fullName":"Oteiza-Rius, I. (Inés)","name":"I.","surname":"Oteiza-Rius","rank":2,"pid":null},{"id":null,"fullName":"Aguado, L. (Leyre)","name":"L.","surname":"Aguado","rank":3,"pid":null}],"openAccessColor":null,"publiclyFunded":null,"eoscIfGuidelines":null,"type":"other","language":{"code":"spa","label":"Spanish; Castilian"},"countries":null,"subjects":[{"subject":{"scheme":"FOS","value":"03 medical and health sciences"},"provenance":null},{"subject":{"scheme":"FOS","value":"0302 clinical medicine"},"provenance":null},{"subject":{"scheme":"keyword","value":"Solid organ transplant recipients"},"provenance":null},{"subject":{"scheme":"keyword","value":"Materias Investigacion::Ciencias de la Salud::Dermatología"},"provenance":null},{"subject":{"scheme":"keyword","value":"Squamous cell carcinoma"},"provenance":null},{"subject":{"scheme":"keyword","value":"Queratosis actínicas"},"provenance":null},{"subject":{"scheme":"keyword","value":"Trasplantados de órgano sólido"},"provenance":null},{"subject":{"scheme":"keyword","value":"Carcinoma escamoso"},"provenance":null},{"subject":{"scheme":"keyword","value":"Actinic keratosis"},"provenance":null},{"subject":{"scheme":"keyword","value":"Immunosuppression"},"provenance":null},{"subject":{"scheme":"keyword","value":"Inmunosupresión"},"provenance":null}],"mainTitle":"Queratosis actínicas en pacientes trasplantados de órgano sólido: revisión de la literatura","subTitle":null,"descriptions":["La inmunosupresión farmacológica de los pacientes trasplantados de órgano solido constituye un importante factor de riesgo tanto para la aparición de queratosis actínicas (QA) como para su progresión a carcinomas escamosos (CE). El tratamiento tanto de las lesiones clí- nicas como preclínicas en este grupo de pacientes es obligatorio debido a la elevada posibilidad de evolución a CE. Por otra parte, la prevención presenta también un papel importante que debemos tener en cuenta. Existen un gran número de estudios realizados en pacientes inmunocompetentes sobre el tratamiento y la prevención de QA, pero no en pacientes inmunosuprimidos. Esta revisión pretende resumir el conocimiento actual sobre los tratamientos y medidas de prevención de la QA en loas pacientes trasplantados de órgano sólido."],"publicationDate":"2023-01-01","publisher":"Academia Española de Dermatología y Venereología (AEDV)","embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Repositorio de la Universidad de Navarra"],"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":null,"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"00064aabbda9::03802728b82aefc940512e7ca132acee","originalIds":["50|00064aabbda9::03802728b82aefc940512e7ca132acee","oai:navarra.escire.net:10171/68501"],"pids":[{"scheme":"handle","value":"10171/68501"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":0.0,"influence":2.1746283E-9,"popularity":1.6835128E-9,"impulse":0.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"projects":null,"organizations":null,"communities":null,"collectedFrom":[{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}],"instances":[{"pids":[{"scheme":"handle","value":"10171/68501"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Other ORP type","urls":["https://hdl.handle.net/10171/68501"],"publicationDate":"2023-01-01","refereed":"nonPeerReviewed","hostedBy":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"},"collectedFrom":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}}],"links":null,"otherTitles":["Actinic Keratosis in Solid Organ Transplant Recipients: A Medical Literature Review"],"inDiamondJournal":null,"green":null,"isGreen":null,"isInDiamondJournal":null},{"authors":[{"id":null,"fullName":"Claveria-Cabello, A. (Alex)","name":"A.","surname":"Claveria-Cabello","rank":1,"pid":null}],"openAccessColor":null,"publiclyFunded":null,"eoscIfGuidelines":null,"type":"other","language":{"code":"eng","label":"English"},"countries":null,"subjects":[{"subject":{"scheme":"keyword","value":"Materias Investigacion::Ciencias de la Salud::Hepatología"},"provenance":null},{"subject":{"scheme":"keyword","value":"Hepatoblastoma"},"provenance":null},{"subject":{"scheme":"keyword","value":"Epigenetic mechanisms"},"provenance":null},{"subject":{"scheme":"keyword","value":"Chronic liver disease"},"provenance":null},{"subject":{"scheme":"keyword","value":"Liver fibrosis"},"provenance":null},{"subject":{"scheme":"keyword","value":"Pediatric liver cancer"},"provenance":null}],"mainTitle":"Epigenetic mechanisms in chronic liver disease and pediatric liver cancer","subTitle":null,"descriptions":["Numerosas evidencias apoyan cada vez más la relevancia de los mecanismos epigenéticos en la progresión de la enfermedad hepática crónica y en el desarrollo de tumores hepáticos. Si bien estos procesos son esenciales en el establecimiento y preservación de la identidad celular, su alteración tiene un fuerte impacto en el desarrollo de la enfermedad hepática. El conocimiento de tales alteraciones epigenéticas es esencial para entender mejor los mecanismos fisiopatológicos que acontecen, destacando asimismo su reversibilidad, convirtiendo su modulación en potenciales herramientas terapéuticas. El presente trabajo se ha focalizado en la caracterización de mecanismos epigenéticos clave en la progresión de la fibrosis hepática y en el desarrollo del principal tumor hepático infantil denominado hepatoblastoma (HB), así como en el potencial terapéutico con nuevas moléculas inhibidoras de tales mecanismos desarrolladas en nuestra institución. Capitulo 1. La enfermedad crónica del hígado tiene como denominador común el desarrollo de fibrosis hepática. Este fenómeno comporta la activación de células estrelladas hepáticas hacia un fenotipo miofibroblástico secretor de matriz extracelular y responsable de la perpetuación del proceso fibrogénico. La adquisición de este fenotipo está fuertemente regulado por mecanismos epigenéticos, entre los que destacan la acetilacióndeacetilación de histonas. Por otro lado, las células estrelladas activadas sufren una desregulación de la vía del GMPc que provoca una caída de sus niveles debido a la actividad de la fosfodiesteresa 5 (PDE5). Es por ello que se evaluó los efectos de un inhibidor dual de histonas deacetilasas (HDAC) y PDE5 desarrollado en el CIMA (CM414) en un modelo clínicamente relevante de fibrosis en ratón (Mdr2-KO). Los resultados demostraron que el CM414 fue capaz de reducir la deposición de matriz extracelular en los ratones, atenuar la reacción ductular y la activación de los fibroblastos portales. Asimismo, el CM414 presentó efectos anti-inflamatorios, reduciendo la infiltración de leucocitos y la expresión de genes proinflamatorios. Estudios mecanísticos demostraron como el CM414 atenuó la activación de una línea inmortalizada de células estrellas hepáticas (LX2) mediante la inhibición de la vía de PI3K-AKT y la vía de ß-catenin. Por último, los efectos anti-inflamatorios del CM414 fueron validados en LX2 y en una línea de macrófago de ratón RAW264.7, donde se observó una represión de la vía de señalización de NF-kB mediada por LPS. Capítulo 2. Estudios previos han establecido como determinadas subclasificaciones epigenéticas están asociadas a un peor pronóstico, y han demostrado cómo mecanismos epigenéticos tales como la metilación del ADN y las modificaciones de histonas juegan un papel relevante en la represión de genes supresores de tumores en HB. De hecho, esa represión se debe a un incremento de la metilación en sus promotores mediada por la DNMT1, acompañado por un incremento de la marca represiva de la histona 3 H3K9me2 (depositada por G9a). En este capítulo se demostró como los modificadores epigenéticos G9a y DNMT1 se encuentran sobreexpresados en los tumores de HB y que su expresión se incrementa de manera más acusada en aquellos tumores de peor pronóstico. La inhibición dual de G9a-DNMT1 con el fármaco CM272 también desarrollado en el CIMA redujo la viabilidad de células de HB in vitro e in vivo. La inhibición específica de G9a reprimió la expresión de genes cruciales en el metabolismo tumoral de aminoácidos (Aa) a través de la inhibición de importantes factores de transcripción, tales como MYC y ATF4 en las células de HB. El tratamiento con CM272 fue capaz de interrumpir la respuesta de las células a la restricción de Aa mediada por ATF4. Por último, se demostró cómo la ausencia de G9a en el hepatocito evitó el desarrollo de HB en un modelo experimental de ratón inducido por la inyección hidrodinámica de formas constitutivamente activas de YAP y ß-catenina."],"publicationDate":"2023-11-16","publisher":"Universidad de Navarra","embargoEndDate":null,"sources":null,"formats":["application/pdf"],"contributors":["Avila, M.A. (Matías Antonio)","García-Fernández-de-Barrena, M. (Maite)","Repositorio de la Universidad de Navarra"],"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":null,"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"00064aabbda9::03984508bd3132e4a04fb7037a0f45fa","originalIds":["oai:navarra.escire.net:10171/67874","50|00064aabbda9::03984508bd3132e4a04fb7037a0f45fa"],"pids":[{"scheme":"handle","value":"10171/67874"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":0.0,"influence":2.1746283E-9,"popularity":1.6835128E-9,"impulse":0.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"projects":null,"organizations":null,"communities":[{"code":"cancer-research","label":"Cancer Research","provenance":null}],"collectedFrom":[{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}],"instances":[{"pids":[{"scheme":"handle","value":"10171/67874"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Other ORP type","urls":["https://hdl.handle.net/10171/67874"],"publicationDate":"2023-11-16","refereed":"nonPeerReviewed","hostedBy":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"},"collectedFrom":{"key":"openaire____::891381590337449b8dfd6259d4031ae1","value":"NAVARA SCIRE"}}],"links":null,"otherTitles":null,"inDiamondJournal":null,"green":null,"isGreen":null,"isInDiamondJournal":null}]}