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For the validation in anal cancer, a dataset of 59 patients coming from two different centers was collected. The primary endpoint was HPV status according to p16 immunohistochemistry. Predefined statistical tests were performed to evaluate the performance of the model. The AUC obtained here in anal cancer is 0.68 [95% CI (0.32–1.00)] with F1 score of 0.78. This signature is TRIPOD level 4 (57%) with an RQS of 61%. 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