{"authors":[{"id":null,"fullName":"Panda, Mrutyunjaya","name":"Mrutyunjaya","surname":"Panda","rank":1,"pid":{"id":{"scheme":"orcid_pending","value":"0000-0002-5652-3316"},"provenance":null}}],"openAccessColor":null,"publiclyFunded":false,"eoscIfGuidelines":null,"type":"publication","language":{"code":"eng","label":"English"},"countries":null,"subjects":[{"subject":{"scheme":"FOS","value":"03 medical and health sciences"},"provenance":null},{"subject":{"scheme":"FOS","value":"0302 clinical medicine"},"provenance":null},{"subject":{"scheme":"keyword","value":"Metabolism"},"provenance":null},{"subject":{"scheme":"keyword","value":"Alzheimer Disease"},"provenance":null},{"subject":{"scheme":"keyword","value":"Mitophagy"},"provenance":null},{"subject":{"scheme":"keyword","value":"Autophagy"},"provenance":null},{"subject":{"scheme":"keyword","value":"Caenorhabditis elegans"},"provenance":null},{"subject":{"scheme":"keyword","value":"Circadian Rhythm"},"provenance":null}],"mainTitle":"TClock4AD_DC14_M1-M15","subTitle":null,"descriptions":["MSCA_DN-JD_TClock4AD: Targeting Circadian Clock dysfunction in Alzheimer's DiseaseWork package: WP4. Drug molecular mechanismsProject title: Circadian control of mitochondria-specific autophagy in neuronal degeneration associated with AD  DC14: Mrutyunjaya Panda Supervisors: Nektarios Tavernarakis (FORTH), Gabriela Constantin (UNIVR), Rita Guedes (ULisbon), Javier Iglesias (NBD)Organisations: Foundation for Research and Technology Hellas (FORTH), GR; University of Verona (UNIVR), IT; University of Lisbon (ULisbon), PT; Nostrum Biodiscovery (NBD), SP.  Home institution: Foundation for Research and Technology Hellas – Greece (24 months)  Host institution: Verona University – Italy (10 months)  PhD Enrolment #1: Verona University – Italy   PhD Enrolment #2: Lisbon University – Portugal  Supervisor #1: Nektarios Tavernarakis  Supervisor #2: Gabriela Constantin  Intersectoral Secondment: Nostrum Biodiscovery – Spain  Objectives: Mitochondrial dysfunction and reduced efficacy of mitochondrial quality control mechanisms are hallmarks of ageing and several human pathologies, including age-associated neurodegenerative disorders. We aim to elucidate the role of CC in modulating mitophagy and metabolic functions in AD. Our research plan involves four specific scientific objectives: (i) Generation of transgenic C. elegans strains expressing mitophagy reporters in specific neuronal types; (ii) monitoring mitochondrial turnover at defined time points during life in animal AD models, i.e., transgenic nematodes expressing Aβ or tau in nematode neurons. (iii) Chemical screening for modifiers of neuronal mitophagy and susceptibility to age-associated neurodegeneration. (iv) Assessment of the influence of genetic pathways and interventions known to affect C. elegans ageing on neuronal mitophagy and neurodegeneration in nematode models of AD.  Expected outcomes: To generate breakthrough ideas in the assigned area of research and carry out research in line with the project plan. (i) Novel pathways/mechanisms that link the dysfunction of circadian rhythms with alterations in mitochondrial turnover and neurodegeneration; (ii) Biomolecular and pharmacological modulators that interact with this novel pathway; (iii) 2-3 papers","This folder contains the month 1 to month 15 updates for the TClock4AD DC14 project."],"publicationDate":"2025-04-28","publisher":"TClock4AD","embargoEndDate":null,"sources":null,"formats":null,"contributors":["Tavernarakis, Nektarios"],"coverages":null,"bestAccessRight":{"code":"c_f1cf","label":"EMBARGO","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":null,"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"doi_dedup___::d1dfdf8e63fe65b002c5daea58f0d5c4","originalIds":["50|datacite____::d1dfdf8e63fe65b002c5daea58f0d5c4","10.5281/zenodo.15294768","50|datacite____::ff75925067760e61828a6b0cb639d586","10.5281/zenodo.15294769","oai:zenodo.org:15294769","50|od______2659::ff75925067760e61828a6b0cb639d586"],"pids":[{"scheme":"doi","value":"10.5281/zenodo.15294768"},{"scheme":"doi","value":"10.5281/zenodo.15294769"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":0.0,"influence":2.1746283E-9,"popularity":2.2497804E-9,"impulse":0.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C5"}},"projects":[{"id":"corda_____he::257589aef55b2bc14d5cbc44d5db67da","code":"101072895","acronym":"TClock4AD","title":"Targeting Circadian Clock Dysfunction in Alzheimer’s Disease","funder":"European Commission","pids":[{"scheme":"doi","value":"10.3030/101072895"}]}],"organizations":[{"legalName":"Foundation for Research and Technology Hellas","acronym":"FORTH","id":"openorgs____::5ec3d36c57c96bdfd6ee8183fb247a90","pids":[{"scheme":"fundref","value":"501100012288"},{"scheme":"GRID","value":"grid.4834.b"},{"scheme":"Wikidata","value":"Q56649061"},{"scheme":"FundRef","value":"501100012288"},{"scheme":"OrgRef","value":"2696935"},{"scheme":"PIC","value":"999995893"},{"scheme":"ROR","value":"https://ror.org/052rphn09"},{"scheme":"OrgReg","value":"GR1009"},{"scheme":"mag_id","value":"8901234"},{"scheme":"Wikidata","value":"Q39633068"},{"scheme":"ISNI","value":"000000040635685X"},{"scheme":"wikidata","value":"Q953914"},{"scheme":"Wikidata","value":"Q953914"},{"scheme":"wikidata","value":"Q39633068"}],"countries":[{"code":"GR","label":"Greece"}],"websiteurl":"http://www.forth.gr"}],"communities":[{"code":"eosc","label":"EOSC","provenance":null}],"collectedFrom":[{"key":"openaire____::9e3be59865b2c1c335d32dae2fe7b254","value":"Datacite"},{"key":"opendoar____::358aee4cc897452c00244351e4d91f69","value":"ZENODO"}],"instances":[{"pids":[{"scheme":"doi","value":"10.5281/zenodo.15294768"}],"license":"CC BY","type":"Project deliverable","urls":["https://dx.doi.org/10.5281/zenodo.15294768"],"publicationDate":"2025-04-28","refereed":"nonPeerReviewed","hostedBy":{"key":"opendoar____::358aee4cc897452c00244351e4d91f69","value":"ZENODO"},"collectedFrom":{"key":"openaire____::9e3be59865b2c1c335d32dae2fe7b254","value":"Datacite"}},{"pids":[{"scheme":"doi","value":"10.5281/zenodo.15294769"}],"license":"CC BY","type":"Project deliverable","urls":["https://dx.doi.org/10.5281/zenodo.15294769"],"publicationDate":"2025-04-28","refereed":"nonPeerReviewed","hostedBy":{"key":"opendoar____::358aee4cc897452c00244351e4d91f69","value":"ZENODO"},"collectedFrom":{"key":"openaire____::9e3be59865b2c1c335d32dae2fe7b254","value":"Datacite"}},{"pids":[{"scheme":"doi","value":"10.5281/zenodo.15294769"}],"alternateIdentifiers":[{"scheme":"oai","value":"oai:zenodo.org:15294769"}],"license":"CC BY","accessRight":{"code":"c_f1cf","label":"EMBARGO","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Other literature type","urls":["http://dx.doi.org/10.5281/zenodo.15294769","https://zenodo.org/records/15294769"],"publicationDate":"2025-04-28","refereed":"nonPeerReviewed","hostedBy":{"key":"opendoar____::358aee4cc897452c00244351e4d91f69","value":"ZENODO"},"collectedFrom":{"key":"opendoar____::358aee4cc897452c00244351e4d91f69","value":"ZENODO"}}],"links":[{"header":{"relationType":"resultProject","relationClass":"isProducedBy","relatedIdentifier":"corda_____he::257589aef55b2bc14d5cbc44d5db67da","relatedRecordType":"project","relationProvenance":"sysimport:crosswalk:repository","trust":"0.9"},"collectedfrom":[{"dsId":"openaire____::3f264f93cf3b0cfc4ede188a6300455c","dsName":"CORDA - 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