{"authors":[{"id":"orcid_______::650284888e0b38b230caa6103effea79","fullName":"Prete, A","name":"A","surname":"Prete","rank":1,"pid":{"id":{"scheme":"orcid","value":"0000-0002-4821-0336"},"provenance":null}},{"id":null,"fullName":"Abdi, L","name":"L","surname":"Abdi","rank":2,"pid":null},{"id":"orcid_______::44860b0148920d8bc337c13415eaee53","fullName":"Canducci, M","name":"M","surname":"Canducci","rank":3,"pid":{"id":{"scheme":"orcid","value":"0000-0003-2264-9743"},"provenance":null}},{"id":null,"fullName":"van den Brandhof, EL","name":"EL","surname":"van den Brandhof","rank":4,"pid":null},{"id":null,"fullName":"Albors-Zumel, A","name":"A","surname":"Albors-Zumel","rank":5,"pid":null},{"id":null,"fullName":"Jenkinson, C","name":"C","surname":"Jenkinson","rank":6,"pid":null},{"id":null,"fullName":"Gilligan, LC","name":"LC","surname":"Gilligan","rank":7,"pid":null},{"id":null,"fullName":"Zhang, Y","name":"Y","surname":"Zhang","rank":8,"pid":null},{"id":null,"fullName":"Visser, L","name":"L","surname":"Visser","rank":9,"pid":null},{"id":null,"fullName":"Chortis, V","name":"V","surname":"Chortis","rank":10,"pid":null},{"id":null,"fullName":"Najdekr, L","name":"L","surname":"Najdekr","rank":11,"pid":null},{"id":null,"fullName":"Jankevics, A","name":"A","surname":"Jankevics","rank":12,"pid":null},{"id":null,"fullName":"Lloyd, GR","name":"GR","surname":"Lloyd","rank":13,"pid":null},{"id":null,"fullName":"Winder, CL","name":"CL","surname":"Winder","rank":14,"pid":null},{"id":null,"fullName":"Tsagarakis, S","name":"S","surname":"Tsagarakis","rank":15,"pid":null},{"id":null,"fullName":"Lang, K","name":"K","surname":"Lang","rank":16,"pid":null},{"id":null,"fullName":"Macech, M","name":"M","surname":"Macech","rank":17,"pid":null},{"id":null,"fullName":"Fell, V","name":"V","surname":"Fell","rank":18,"pid":null},{"id":null,"fullName":"Vodanovic, ID","name":"ID","surname":"Vodanovic","rank":19,"pid":null},{"id":null,"fullName":"Reimondo, G","name":"G","surname":"Reimondo","rank":20,"pid":null},{"id":null,"fullName":"Marina, LV","name":"LV","surname":"Marina","rank":21,"pid":null},{"id":null,"fullName":"Deutschbein, T","name":"T","surname":"Deutschbein","rank":22,"pid":null},{"id":null,"fullName":"Balomenaki, M","name":"M","surname":"Balomenaki","rank":23,"pid":null},{"id":null,"fullName":"O'Reilly, MW","name":"MW","surname":"O'Reilly","rank":24,"pid":null},{"id":"orcid_______::5c3323ff9020b0b47cd179b27b83b839","fullName":"Tomasz Marcin Bednarczuk","name":null,"surname":null,"rank":25,"pid":{"id":{"scheme":"orcid","value":"0000-0002-5752-8709"},"provenance":null}},{"id":null,"fullName":"Dusek, T","name":"T","surname":"Dusek","rank":26,"pid":null},{"id":null,"fullName":"Diamantopoulos, A","name":"A","surname":"Diamantopoulos","rank":27,"pid":null},{"id":null,"fullName":"Asia, M","name":"M","surname":"Asia","rank":28,"pid":null},{"id":null,"fullName":"Kondracka, A","name":"A","surname":"Kondracka","rank":29,"pid":null},{"id":null,"fullName":"Yu, K","name":"K","surname":"Yu","rank":30,"pid":null},{"id":null,"fullName":"Masjkur, JR","name":"JR","surname":"Masjkur","rank":31,"pid":null},{"id":null,"fullName":"Quinkler, M","name":"M","surname":"Quinkler","rank":32,"pid":null},{"id":null,"fullName":"Ueland, GÅ","name":"GÅ","surname":"Ueland","rank":33,"pid":null},{"id":null,"fullName":"Dennedy, MC","name":"MC","surname":"Dennedy","rank":34,"pid":null},{"id":null,"fullName":"Beuschlein, F","name":"F","surname":"Beuschlein","rank":35,"pid":null},{"id":null,"fullName":"Tabarin, A","name":"A","surname":"Tabarin","rank":36,"pid":null},{"id":null,"fullName":"Fassnacht, M","name":"M","surname":"Fassnacht","rank":37,"pid":null},{"id":null,"fullName":"Ivovic, M","name":"M","surname":"Ivovic","rank":38,"pid":null},{"id":null,"fullName":"Terzolo, M","name":"M","surname":"Terzolo","rank":39,"pid":null},{"id":null,"fullName":"Kastelan, D","name":"D","surname":"Kastelan","rank":40,"pid":null},{"id":null,"fullName":"Young, WF","name":"WF","surname":"Young","rank":41,"pid":null},{"id":null,"fullName":"Manolopoulos, KN","name":"KN","surname":"Manolopoulos","rank":42,"pid":null},{"id":"orcid_______::883e93701e44955f244a915696d63272","fullName":"Urszula Anna Ambroziak","name":null,"surname":null,"rank":43,"pid":{"id":{"scheme":"orcid","value":"0000-0002-8778-1959"},"provenance":null}},{"id":null,"fullName":"Vassiliadi, DA","name":"DA","surname":"Vassiliadi","rank":44,"pid":null},{"id":null,"fullName":"Bancos, I","name":"I","surname":"Bancos","rank":45,"pid":null},{"id":null,"fullName":"Sitch, AJ","name":"AJ","surname":"Sitch","rank":46,"pid":null},{"id":null,"fullName":"Taylor, AE","name":"AE","surname":"Taylor","rank":47,"pid":null},{"id":"orcid_______::4e5eb19d02e288aa5f19e088ecb8238a","fullName":"Tino, P","name":"P","surname":"Tino","rank":48,"pid":{"id":{"scheme":"orcid","value":"0000-0003-2330-128x"},"provenance":null}},{"id":"orcid_______::25e34e4bc24a7a80f2784530c1f3cf36","fullName":"Biehl, M","name":"M","surname":"Biehl","rank":49,"pid":{"id":{"scheme":"orcid","value":"0000-0001-5148-4568"},"provenance":null}},{"id":null,"fullName":"Dunn, WB","name":"WB","surname":"Dunn","rank":50,"pid":null},{"id":null,"fullName":"Arlt, W","name":"W","surname":"Arlt","rank":51,"pid":null},{"id":null,"fullName":"ENSAT EURINE-ACT Investigators, ","name":null,"surname":"ENSAT EURINE-ACT Investigators","rank":52,"pid":null}],"openAccessColor":"gold","publiclyFunded":true,"eoscIfGuidelines":null,"type":"publication","language":{"code":"eng","label":"English"},"countries":[{"code":"NL","label":"Netherlands","provenance":null},{"code":"PL","label":"Poland","provenance":null},{"code":"IT","label":"Italy","provenance":null}],"subjects":[{"subject":{"scheme":"FOS","value":"0303 health sciences"},"provenance":null},{"subject":{"scheme":"FOS","value":"03 medical and health sciences"},"provenance":null},{"subject":{"scheme":"keyword","value":"Cortisol excess"},"provenance":null},{"subject":{"scheme":"keyword","value":"Cushing's syndrome"},"provenance":null},{"subject":{"scheme":"keyword","value":"Mild autonomous cortisol secretion"},"provenance":null},{"subject":{"scheme":"keyword","value":"Adrenal incidentaloma; Cortisol excess; Cushing's syndrome; Mild autonomous cortisol secretion; Non-functioning adrenal tumour"},"provenance":null},{"subject":{"scheme":"keyword","value":"Articles"},"provenance":null},{"subject":{"scheme":"keyword","value":"Non-functioning adrenal tumour"},"provenance":null},{"subject":{"scheme":"keyword","value":"Adrenal incidentaloma"},"provenance":null}],"mainTitle":"Endocrine and metabolic determinants of cardiometabolic risk in mild autonomous cortisol secretion","subTitle":null,"descriptions":["Benign adrenal tumours, found in 1-7% of adults, can be non-functioning (NFAT) or show mild autonomous cortisol secretion (MACS), i.e., biochemical cortisol excess without manifestations of Cushing's syndrome (CS). MACS occurs in 20-50% of cases and is linked to increased cardiometabolic burden.In a cross-sectional study, we analysed the 24-h urinary steroid metabolome of 1305 prospectively recruited patients (649 NFAT, 591 MACS, 65 adrenal CS) by tandem mass spectrometry. A sub-group (104 NFAT, 140 MACS, 47 adrenal CS) underwent untargeted serum metabolome analysis by mass spectrometry. Data were analysed using linear regression and supervised machine learning.Alongside the expected increase in glucocorticoid excretion from NFAT over MACS to adrenal CS, steroid analysis revealed decreased classic androgen metabolite excretion. By contrast, adrenal-derived 11-oxygenated androgen metabolites remained unchanged. Both glucocorticoid metabolites and the major 11-oxygenated androgen metabolite 11β-hydroxyandrosterone correlated with a higher risk of hypertension and type 2 diabetes. Untargeted metabolome analysis revealed gradual changes towards a lipotoxic phenotype from NFAT over MACS to adrenal CS, with perturbations in glycerophospholipids, lysoglycerophospholipids, triacylglycerides, ceramides, sphingolipids, and acylcarnitines.MACS represents a metabolic continuum between NFAT and adrenal CS. Increased activity of the adrenal enzyme 11β-hydroxylase (CYP11B1), which catalyses key steps in cortisol and 11-oxygenated androgen biosynthesis, may contribute to steroid excess and cardiometabolic morbidity in MACS. These findings suggest that CYP11B1 may be a potential therapeutic target to ameliorate metabolic dysfunction in MACS.NIHR Birmingham Biomedical Research Centre; Diabetes UK; Wellcome Trust; European Commission; Medical Research Council."],"publicationDate":"2026-02-01","publisher":"Elsevier BV","embargoEndDate":null,"sources":["Crossref","eBioMedicine"],"formats":["application/pdf"],"contributors":null,"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":{"name":"eBioMedicine","issnPrinted":"2352-3964","issnOnline":null,"issnLinking":null,"ep":null,"iss":null,"sp":"106126","vol":"124","edition":null,"conferencePlace":null,"conferenceDate":null},"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"doi_dedup___::cf153dc4eaad2a49c94a06fdb63fe664","originalIds":["S2352396426000071","10.1016/j.ebiom.2026.106126","50|doiboost____|cf153dc4eaad2a49c94a06fdb63fe664","od_______267::f7938e7e4e3e526ec641e95a173fe096","41576621","PMC12860258","50|od_______267::f7938e7e4e3e526ec641e95a173fe096","oai:pubmedcentral.nih.gov:12860258","oai:pure.rug.nl:openaire_cris_publications/830993eb-eb48-4397-ac68-73c457c914f3","50|dris___01423::3eab4672347ca00ffba81ee05dd88120","50|od_____10049::3e46a5b60973913be63e51854d1f5c0c","oai:ppm.edu.pl:Publications/WUM747a2797df854392ba5a46b01da4fce2","oai:localhost:Publications/WUM747a2797df854392ba5a46b01da4fce2","50|od_____10049::4e6161a7f9def9f2dd0b8e509248dcd3","50|od_______970::581c46dbbfe28c113b45a4b0582966da","oai:iris.unito.it:2318/2122411"],"pids":[{"scheme":"doi","value":"10.1016/j.ebiom.2026.106126"},{"scheme":"pmid","value":"41576621"},{"scheme":"pmc","value":"PMC12860258"},{"scheme":"handle","value":"11370/830993eb-eb48-4397-ac68-73c457c914f3"},{"scheme":"handle","value":"2318/2122411"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":2.0,"influence":2.300847E-9,"popularity":4.0487054E-9,"impulse":2.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C5","popularityClass":"C4"}},"projects":[{"id":"corda_____he::c38637d43badadacec8bea9e3689b01f","code":"101095407","acronym":"HT-ADVANCE","title":"Improving treatment efficacy in hypertension by biomarker-guided personalised decision support","funder":"European Commission","pids":[{"scheme":"doi","value":"10.3030/101095407"}]},{"id":"ukri________::7cc88f57292668ae35658b07571a291d","code":"MR/M009157/1","acronym":null,"title":"Integrating innovative technologies for genotyping and phenotyping in stratified medicine","funder":"UK Research and Innovation","pids":null},{"id":"dfgf________::1e5e62235d094afd01cd56e65112fc63","code":"unidentified","acronym":null,"title":"unidentified","funder":"Deutsche Forschungsgemeinschaft","pids":null},{"id":"ukri________::d20b8afe4a54b76f72a0713fe5c09bc3","code":"G0801473","acronym":null,"title":"Steroid profiling as a biomarker tool in the diagnosis and monitoring of adrenal tumours","funder":"UK Research and Innovation","pids":null}],"organizations":[{"legalName":"University of Liverpool","acronym":"University of Liverpool","id":"openorgs____::4dde77cd192e5101fe0a317e00ba3827","pids":[{"scheme":"OrgReg","value":"UK0069"},{"scheme":"GRID","value":"grid.10025.36"},{"scheme":"OrgRef","value":"156512"},{"scheme":"wikidata","value":"Q499510"},{"scheme":"ROR","value":"https://ror.org/04xs57h96"},{"scheme":"RRID","value":"RRID:SCR_005424"},{"scheme":"HESA","value":"0126"},{"scheme":"FundRef","value":"501100000836"},{"scheme":"RRID","value":"RRID:nlx_50695"},{"scheme":"Wikidata","value":"Q499510"},{"scheme":"UCAS","value":"L41"},{"scheme":"fundref","value":"501100000836"},{"scheme":"mag_id","value":"146655781"},{"scheme":"ISNI","value":"0000000419368470"},{"scheme":"UKPRN","value":"10006842"},{"scheme":"PIC","value":"999980567"}]},{"legalName":"University of Würzburg","acronym":"University of Würzburg","id":"openorgs____::47b50b8e44019cc77db4119bbd6b3657","pids":[{"scheme":"Wikidata","value":"Q161976"},{"scheme":"OrgReg","value":"DE0027"},{"scheme":"wikidata","value":"Q161976"},{"scheme":"GRID","value":"grid.8379.5"},{"scheme":"ISNI","value":"0000000119588658"},{"scheme":"FundRef","value":"501100008769"},{"scheme":"mag_id","value":"25974101"},{"scheme":"fundref","value":"501100009379"},{"scheme":"RRID","value":"RRID:SCR_007008"},{"scheme":"ROR","value":"https://ror.org/00fbnyb24"},{"scheme":"fundref","value":"501100008769"},{"scheme":"PIC","value":"999853206"},{"scheme":"OrgRef","value":"715155"},{"scheme":"FundRef","value":"501100009379"}]},{"legalName":"TU Dresden","acronym":"TUD","id":"openorgs____::a6340e6ecf60f6bba163659df985b0f2","pids":[{"scheme":"fundref","value":"501100007491"},{"scheme":"RRID","value":"RRID:nlx_53167"},{"scheme":"ISNI","value":"0000000121117257"},{"scheme":"FundRef","value":"501100023321"},{"scheme":"fundref","value":"501100020132"},{"scheme":"RRID","value":"RRID:SCR_004799"},{"scheme":"Wikidata","value":"Q158158"},{"scheme":"OrgReg","value":"DE0094"},{"scheme":"GRID","value":"grid.4488.0"},{"scheme":"ROR","value":"https://ror.org/042aqky30"},{"scheme":"fundref","value":"501100002957"},{"scheme":"FundRef","value":"501100002957"},{"scheme":"Wikidata","value":"Q31837129"},{"scheme":"FundRef","value":"501100007491"},{"scheme":"FundRef","value":"501100020132"},{"scheme":"OrgRef","value":"827048"},{"scheme":"PIC","value":"983820270"},{"scheme":"fundref","value":"501100023321"},{"scheme":"wikidata","value":"Q31837129"},{"scheme":"PIC","value":"999897729"},{"scheme":"wikidata","value":"Q158158"}]},{"legalName":"University of Zurich","acronym":"UZH","id":"openorgs____::3514a58d10bfa5be292024c2b7a6ee6c","pids":[{"scheme":"fundref","value":"501100014357"},{"scheme":"ROR","value":"https://ror.org/02crff812"},{"scheme":"fundref","value":"501100006448"},{"scheme":"OrgRef","value":"314803"},{"scheme":"FundRef","value":"501100003290"},{"scheme":"mag_id","value":"202697423"},{"scheme":"wikidata","value":"Q206702"},{"scheme":"GRID","value":"grid.7400.3"},{"scheme":"PIC","value":"999976396"},{"scheme":"Wikidata","value":"Q206702"},{"scheme":"fundref","value":"100012545"},{"scheme":"ISNI","value":"0000000419370650"},{"scheme":"OrgReg","value":"CH0009"},{"scheme":"fundref","value":"501100008481"},{"scheme":"RRID","value":"RRID:SCR_000342"},{"scheme":"FundRef","value":"501100006447"},{"scheme":"FundRef","value":"501100008481"},{"scheme":"FundRef","value":"501100006448"},{"scheme":"fundref","value":"501100003290"},{"scheme":"fundref","value":"501100006447"},{"scheme":"FundRef","value":"501100014357"},{"scheme":"FundRef","value":"100012545"}]},{"legalName":"Imperial College London","acronym":"Imperial College London","id":"openorgs____::778fb8061fc9d6356293bec4c38fb72f","pids":[{"scheme":"fundref","value":"501100024415"},{"scheme":"FundRef","value":"501100014534"},{"scheme":"UCAS","value":"I50"},{"scheme":"mag_id","value":"47508984"},{"scheme":"FundRef","value":"501100024012"},{"scheme":"GRID","value":"grid.7445.2"},{"scheme":"ROR","value":"https://ror.org/041kmwe10"},{"scheme":"ISNI","value":"0000000121138111"},{"scheme":"UKPRN","value":"10003270"},{"scheme":"fundref","value":"501100014534"},{"scheme":"OrgRef","value":"61116"},{"scheme":"OrgReg","value":"UK0053"},{"scheme":"OrgRef","value":"2244827"},{"scheme":"wikidata","value":"Q189022"},{"scheme":"FundRef","value":"501100022211"},{"scheme":"Wikidata","value":"Q189022"},{"scheme":"fundref","value":"501100000761"},{"scheme":"FundRef","value":"501100000850"},{"scheme":"fundref","value":"501100000850"},{"scheme":"HESA","value":"0132"},{"scheme":"RRID","value":"RRID:SCR_011293"},{"scheme":"RRID","value":"RRID:nlx_21884"},{"scheme":"FundRef","value":"501100000761"},{"scheme":"OrgRef","value":"2244729"},{"scheme":"fundref","value":"501100024012"},{"scheme":"FundRef","value":"501100024415"},{"scheme":"fundref","value":"501100022211"}]},{"legalName":"University of Belgrade","acronym":"University of Belgrade","id":"openorgs____::1ec924b1759bb16d0a02f2dad8689b21","pids":[{"scheme":"wikidata","value":"Q240631"},{"scheme":"ROR","value":"https://ror.org/02qsmb048"},{"scheme":"OrgRef","value":"918895"},{"scheme":"fundref","value":"501100024112"},{"scheme":"FundRef","value":"501100024113"},{"scheme":"PIC","value":"999641843"},{"scheme":"fundref","value":"501100024113"},{"scheme":"FundRef","value":"100009574"},{"scheme":"Wikidata","value":"Q1664939"},{"scheme":"FundRef","value":"501100024112"},{"scheme":"ISNI","value":"0000000121669385"},{"scheme":"fundref","value":"100009574"},{"scheme":"GRID","value":"grid.7149.b"},{"scheme":"OrgReg","value":"RS0001"},{"scheme":"mag_id","value":"4068193"},{"scheme":"Wikidata","value":"Q240631"}]},{"legalName":"Ludwig-Maximilians-Universität München","acronym":"LMU","id":"openorgs____::a3caad3e06b6235bdbfe47b3d0568909","pids":[{"scheme":"PIC","value":"999978433"},{"scheme":"RRID","value":"RRID:SCR_011358"},{"scheme":"FundRef","value":"501100014999"},{"scheme":"OrgReg","value":"DE0021"},{"scheme":"ISNI","value":"000000041936973X"},{"scheme":"FundRef","value":"501100005722"},{"scheme":"mag_id","value":"8204097"},{"scheme":"Wikidata","value":"Q55044"},{"scheme":"OrgRef","value":"252750"},{"scheme":"RRID","value":"RRID:nlx_28705"},{"scheme":"fundref","value":"501100014999"},{"scheme":"fundref","value":"501100006192"},{"scheme":"FundRef","value":"501100009401"},{"scheme":"wikidata","value":"Q55044"},{"scheme":"GRID","value":"grid.5252.0"},{"scheme":"fundref","value":"501100005722"},{"scheme":"fundref","value":"501100009401"},{"scheme":"ROR","value":"https://ror.org/05591te55"},{"scheme":"FundRef","value":"501100006192"}]},{"legalName":"Centre Hospitalier Universitaire de Bordeaux","acronym":"CHU","id":"openorgs____::e46bfd95ef48cbf31a8612bc4da88353","pids":[{"scheme":"RNSR","value":"RNSR:201119462L"},{"scheme":"RNSR","value":"RNSR:200316296E"},{"scheme":"GRID","value":"grid.42399.35"},{"scheme":"mag_id","value":"3018323443"},{"scheme":"ISNI","value":"0000000405937118"},{"scheme":"OrgReg","value":"FR2059"},{"scheme":"ROR","value":"https://ror.org/01hq89f96"},{"scheme":"fundref","value":"501100010457"},{"scheme":"FundRef","value":"501100010457"}]},{"legalName":"Clinical Center Serbia","acronym":"KCS","id":"openorgs____::c2f2289edd6d8c52abc0463175bdce93","pids":[{"scheme":"ROR","value":"https://ror.org/02122at02"},{"scheme":"ISNI","value":"0000000087431110"},{"scheme":"GRID","value":"grid.418577.8"},{"scheme":"wikidata","value":"Q12752817"},{"scheme":"PIC","value":"994898058"},{"scheme":"Wikidata","value":"Q12752817"}]},{"legalName":"National Institute for Health Research","acronym":"NIHR","id":"openorgs____::c94329ecc344805ad3f50ae49c7400d7","pids":[{"scheme":"ROR","value":"https://ror.org/0187kwz08"},{"scheme":"fundref","value":"501100000664"},{"scheme":"fundref","value":"100018336"},{"scheme":"FundRef","value":"501100009127"},{"scheme":"fundref","value":"501100001923"},{"scheme":"fundref","value":"501100022224"},{"scheme":"ISNI","value":"0000000121163923"},{"scheme":"FundRef","value":"501100007602"},{"scheme":"FundRef","value":"501100022224"},{"scheme":"fundref","value":"501100001881"},{"scheme":"FundRef","value":"501100009129"},{"scheme":"FundRef","value":"501100000664"},{"scheme":"fundref","value":"501100007602"},{"scheme":"mag_id","value":"34931013"},{"scheme":"fundref","value":"501100000272"},{"scheme":"wikidata","value":"Q6973576"},{"scheme":"fundref","value":"501100009127"},{"scheme":"fundref","value":"501100000659"},{"scheme":"fundref","value":"501100001921"},{"scheme":"fundref","value":"501100009129"},{"scheme":"FundRef","value":"501100000272"},{"scheme":"FundRef","value":"100018336"},{"scheme":"FundRef","value":"501100001923"},{"scheme":"fundref","value":"501100009270"},{"scheme":"FundRef","value":"501100009270"},{"scheme":"FundRef","value":"501100000659"},{"scheme":"FundRef","value":"501100002001"},{"scheme":"fundref","value":"501100009128"},{"scheme":"GRID","value":"grid.451056.3"},{"scheme":"FundRef","value":"501100001881"},{"scheme":"Wikidata","value":"Q6973576"},{"scheme":"fundref","value":"501100001922"},{"scheme":"fundref","value":"501100002001"},{"scheme":"FundRef","value":"501100001922"},{"scheme":"FundRef","value":"501100001921"},{"scheme":"FundRef","value":"501100009128"}]},{"legalName":"University of Trento","acronym":"University of Trento","id":"openorgs____::db652e6496b6c6a08d25533f27864d04","pids":[{"scheme":"ROR","value":"https://ror.org/05trd4x28"},{"scheme":"OrgRef","value":"1949698"},{"scheme":"fundref","value":"501100004004"},{"scheme":"OrgReg","value":"IT0085"},{"scheme":"GRID","value":"grid.11696.39"},{"scheme":"ISNI","value":"0000000419370351"},{"scheme":"wikidata","value":"Q930528"},{"scheme":"Wikidata","value":"Q930528"},{"scheme":"mag_id","value":"193223587"},{"scheme":"FundRef","value":"501100004004"},{"scheme":"PIC","value":"999841954"}]},{"legalName":"University of Turin","acronym":"UNITO","id":"openorgs____::2056a9e24658ecaabdb32a9ba31b16df","pids":[{"scheme":"OrgRef","value":"453828"},{"scheme":"fundref","value":"501100006692"},{"scheme":"mag_id","value":"55143463"},{"scheme":"wikidata","value":"Q499911"},{"scheme":"GRID","value":"grid.7605.4"},{"scheme":"ROR","value":"https://ror.org/048tbm396"},{"scheme":"OrgReg","value":"IT0083"},{"scheme":"FundRef","value":"501100006692"},{"scheme":"FundRef","value":"501100002903"},{"scheme":"ISNI","value":"0000000123366580"},{"scheme":"RRID","value":"RRID:SCR_017007"},{"scheme":"Wikidata","value":"Q499911"},{"scheme":"PIC","value":"999861936"}]},{"legalName":"Saolta University Health Care Group","acronym":"Saolta University Health Care Group","id":"openorgs____::955e601013973254feb42c640f9dc57c","pids":[{"scheme":"ISNI","value":"0000000404107403"},{"scheme":"Wikidata","value":"Q17089713"},{"scheme":"ROR","value":"https://ror.org/03w2xw870"},{"scheme":"wikidata","value":"Q17089713"},{"scheme":"GRID","value":"grid.460983.0"},{"scheme":"OrgRef","value":"41612611"}]},{"legalName":"University of Groningen","acronym":"University of Groningen","id":"openorgs____::81371ea94b1a09d3243e73d6ec3527ec","pids":[{"scheme":"PIC","value":"999989782"},{"scheme":"GRID","value":"grid.4830.f"},{"scheme":"RRID","value":"RRID:nlx_149167"},{"scheme":"Wikidata","value":"Q850730"},{"scheme":"wikidata","value":"Q2303629"},{"scheme":"fundref","value":"501100001721"},{"scheme":"FundRef","value":"501100001721"},{"scheme":"wikidata","value":"Q850730"},{"scheme":"Wikidata","value":"Q2303629"},{"scheme":"fundref","value":"501100001903"},{"scheme":"FundRef","value":"501100001903"},{"scheme":"ISNI","value":"0000000404071981"},{"scheme":"ROR","value":"https://ror.org/012p63287"},{"scheme":"mag_id","value":"169381384"},{"scheme":"OrgReg","value":"NL0006"},{"scheme":"OrgRef","value":"255460"},{"scheme":"RRID","value":"RRID:SCR_011650"}]},{"legalName":"Centre Hospitalier Universitaire de Caen","acronym":"CHU","id":"openorgs____::574d10b5a9a8761669d420239a9a3183","pids":[{"scheme":"OrgReg","value":"FR2104"},{"scheme":"PIC","value":"952694425"},{"scheme":"RNSR","value":"RNSR:201923260E"},{"scheme":"GRID","value":"grid.411149.8"},{"scheme":"ISNI","value":"0000000404720160"},{"scheme":"ROR","value":"https://ror.org/027arzy69"}]},{"legalName":"Mayo Clinic","acronym":"Mayo Clinic","id":"openorgs____::5a2a4cdc063415e78762a3c4c4e80619","pids":[{"scheme":"Wikidata","value":"Q1130172"},{"scheme":"fundref","value":"100000871"},{"scheme":"wikidata","value":"Q1130172"},{"scheme":"ISNI","value":"000000040459167X"},{"scheme":"GRID","value":"grid.66875.3a"},{"scheme":"OrgRef","value":"5488578"},{"scheme":"fundref","value":"100007048"},{"scheme":"FundRef","value":"100000871"},{"scheme":"FundRef","value":"100007048"},{"scheme":"ROR","value":"https://ror.org/02qp3tb03"},{"scheme":"mag_id","value":"1330342723"},{"scheme":"OrgRef","value":"160843"}]},{"legalName":"National Health Service","acronym":"NHS","id":"openorgs____::ff61d34631c46aab86aa322476dd52f8","pids":[{"scheme":"FundRef","value":"501100023864"},{"scheme":"GRID","value":"grid.451052.7"},{"scheme":"ROR","value":"https://ror.org/02wnqcb97"},{"scheme":"fundref","value":"501100023864"},{"scheme":"ISNI","value":"0000000405812008"},{"scheme":"wikidata","value":"Q16251481"},{"scheme":"mag_id","value":"125671874"},{"scheme":"Wikidata","value":"Q16251481"}]},{"legalName":"Queen Elizabeth Hospital","acronym":"Queen Elizabeth Hospital","id":"openorgs____::c95ac3367f5067f09ae5b74e1f16625b","pids":[{"scheme":"Wikidata","value":"Q7270338"},{"scheme":"ISNI","value":"0000000404003364"},{"scheme":"ROR","value":"https://ror.org/015dyrs73"},{"scheme":"wikidata","value":"Q7270338"},{"scheme":"GRID","value":"grid.415506.3"}]},{"legalName":"Haukeland University Hospital","acronym":"Haukeland University Hospital","id":"openorgs____::fcbbb92d890f32f87af39100d287857c","pids":[{"scheme":"mag_id","value":"2800740805"},{"scheme":"ISNI","value":"0000000097531393"},{"scheme":"ROR","value":"https://ror.org/03np4e098"},{"scheme":"GRID","value":"grid.412008.f"},{"scheme":"fundref","value":"501100010586"},{"scheme":"Wikidata","value":"Q1770239"},{"scheme":"wikidata","value":"Q1770239"},{"scheme":"OrgRef","value":"12577616"},{"scheme":"OrgReg","value":"NO2005"},{"scheme":"FundRef","value":"501100010586"}]},{"legalName":"Health Service Executive","acronym":"Health Service Executive","id":"openorgs____::9b3fd02daf7da98893cd93dfbc557b71","pids":[{"scheme":"OrgRef","value":"4017657"},{"scheme":"FundRef","value":"100018270"},{"scheme":"fundref","value":"100018270"},{"scheme":"wikidata","value":"Q5690681"},{"scheme":"PIC","value":"993521919"},{"scheme":"GRID","value":"grid.424617.2"},{"scheme":"ROR","value":"https://ror.org/04zke5364"},{"scheme":"mag_id","value":"37076085"},{"scheme":"Wikidata","value":"Q5690681"}]},{"legalName":"Hôpital Cardiologique du Haut-Lévêque","acronym":"Hôpital Cardiologique du Haut-Lévêque","id":"openorgs____::f1f125db6d96d16294fb0d3aa3b098d9","pids":[{"scheme":"GRID","value":"grid.469409.6"},{"scheme":"ROR","value":"https://ror.org/02bf3a828"}]},{"legalName":"University Hospital Galway","acronym":"GUH","id":"openorgs____::202c8b7dfd72ac63fdf7b1fc99035e5e","pids":[{"scheme":"ISNI","value":"0000000406179371"},{"scheme":"mag_id","value":"2802635630"},{"scheme":"OrgRef","value":"7862220"},{"scheme":"OrgReg","value":"IE2001"},{"scheme":"ROR","value":"https://ror.org/04scgfz75"},{"scheme":"wikidata","value":"Q7894625"},{"scheme":"Wikidata","value":"Q7894625"},{"scheme":"GRID","value":"grid.412440.7"}]},{"legalName":"Medical University of Warsaw","acronym":"Medical University of Warsaw","id":"openorgs____::0c9e8c778d9f357dca2581dac8546b05","pids":[{"scheme":"GRID","value":"grid.13339.3b"},{"scheme":"wikidata","value":"Q496351"},{"scheme":"FundRef","value":"501100004166"},{"scheme":"OrgRef","value":"2255815"},{"scheme":"PIC","value":"999878329"},{"scheme":"OrgReg","value":"PL0221"},{"scheme":"ISNI","value":"0000000113287408"},{"scheme":"ROR","value":"https://ror.org/04p2y4s44"},{"scheme":"Wikidata","value":"Q496351"},{"scheme":"mag_id","value":"268303160"},{"scheme":"fundref","value":"501100004166"}]},{"legalName":"University Medical Center Groningen","acronym":"UMCG","id":"openorgs____::e1c228979333191a8f4bd6b5f5d01644","pids":[{"scheme":"FundRef","value":"501100005075"},{"scheme":"OrgReg","value":"NL2007"},{"scheme":"mag_id","value":"1334415907"},{"scheme":"fundref","value":"501100005075"},{"scheme":"GRID","value":"grid.4494.d"},{"scheme":"OrgRef","value":"10637920"},{"scheme":"wikidata","value":"Q2057113"},{"scheme":"ISNI","value":"0000000095584598"},{"scheme":"ROR","value":"https://ror.org/03cv38k47"},{"scheme":"PIC","value":"999914801"},{"scheme":"Wikidata","value":"Q2057113"}]},{"legalName":"Wrocław Medical University","acronym":"Wrocław Medical University","id":"openorgs____::5ad6cfb10ef745ebed4c3b1a7d40f16a","pids":[{"scheme":"FundRef","value":"501100009687"},{"scheme":"fundref","value":"501100009687"},{"scheme":"mag_id","value":"385303915"},{"scheme":"OrgRef","value":"446709"},{"scheme":"PIC","value":"998757300"},{"scheme":"ISNI","value":"000000011090049X"},{"scheme":"Wikidata","value":"Q1916589"},{"scheme":"GRID","value":"grid.4495.c"},{"scheme":"wikidata","value":"Q1916589"},{"scheme":"ROR","value":"https://ror.org/01qpw1b93"}]},{"legalName":"Evangelismos Hospital","acronym":"Evangelismos Hospital","id":"openorgs____::ccb736a607ef0867bd10d3409b129611","pids":[{"scheme":"OrgReg","value":"GR2007"},{"scheme":"ROR","value":"https://ror.org/05q4veh78"},{"scheme":"ISNI","value":"0000000446704329"},{"scheme":"GRID","value":"grid.414655.7"}]},{"legalName":"University of Galway","acronym":"NUIG","id":"openorgs____::779a8a32265c1db7ea6d941ac041e3cd","pids":[{"scheme":"GRID","value":"grid.6142.1"},{"scheme":"FundRef","value":"501100001634"},{"scheme":"FundRef","value":"100007630"},{"scheme":"OrgReg","value":"IE0003"},{"scheme":"OrgRef","value":"36316111"},{"scheme":"fundref","value":"501100001634"},{"scheme":"ISNI","value":"0000000404880789"},{"scheme":"PIC","value":"999978045"},{"scheme":"mag_id","value":"188760350"},{"scheme":"ROR","value":"https://ror.org/03bea9k73"},{"scheme":"wikidata","value":"Q644478"},{"scheme":"Wikidata","value":"Q644478"},{"scheme":"fundref","value":"100007630"},{"scheme":"OrgRef","value":"172910"}]},{"legalName":"Royal College of Surgeons in Ireland","acronym":"RCSI","id":"openorgs____::22760f2e3072a6fdf325adbcec9d136f","pids":[{"scheme":"GRID","value":"grid.4912.e"},{"scheme":"PIC","value":"999867368"},{"scheme":"ROR","value":"https://ror.org/01hxy9878"},{"scheme":"OrgReg","value":"IE0025"},{"scheme":"wikidata","value":"Q1124228"},{"scheme":"Wikidata","value":"Q1124228"},{"scheme":"FundRef","value":"100012921"},{"scheme":"OrgRef","value":"1804872"},{"scheme":"mag_id","value":"142762351"},{"scheme":"ISNI","value":"0000000404887120"},{"scheme":"fundref","value":"100012921"}]},{"legalName":"University Hospital Centre Zagreb","acronym":"University Hospital Centre Zagreb","id":"openorgs____::fc155bdd1450aa54f01b5d8627fd4cdd","pids":[{"scheme":"mag_id","value":"138937732"},{"scheme":"OrgRef","value":"24131974"},{"scheme":"ROR","value":"https://ror.org/00r9vb833"},{"scheme":"Wikidata","value":"Q3504844"},{"scheme":"OrgReg","value":"HR2002"},{"scheme":"ISNI","value":"0000000403979648"},{"scheme":"wikidata","value":"Q3504844"},{"scheme":"PIC","value":"994956064"},{"scheme":"GRID","value":"grid.412688.1"}]},{"legalName":"University Hospitals Birmingham NHS Foundation Trust","acronym":"UHB","id":"openorgs____::919169e8c837bde5bb38b2829285064b","pids":[{"scheme":"OrgReg","value":"UK2006"},{"scheme":"fundref","value":"100013963"},{"scheme":"GRID","value":"grid.412563.7"},{"scheme":"wikidata","value":"Q7894775"},{"scheme":"ISNI","value":"0000000403766589"},{"scheme":"FundRef","value":"100013963"},{"scheme":"mag_id","value":"1308923049"},{"scheme":"ROR","value":"https://ror.org/014ja3n03"},{"scheme":"Wikidata","value":"Q7894775"}]},{"legalName":"University of Birmingham","acronym":"University of Birmingham","id":"openorgs____::2c2b7387e474f86cc1a7aa1d551e2251","pids":[{"scheme":"UCAS","value":"B32"},{"scheme":"HESA","value":"0110"},{"scheme":"UKPRN","value":"10006840"},{"scheme":"fundref","value":"501100000855"},{"scheme":"OrgReg","value":"UK0008"},{"scheme":"fundref","value":"501100020585"},{"scheme":"mag_id","value":"79619799"},{"scheme":"wikidata","value":"Q223429"},{"scheme":"PIC","value":"999907526"},{"scheme":"fundref","value":"501100024311"},{"scheme":"Wikidata","value":"Q223429"},{"scheme":"ISNI","value":"0000000419367486"},{"scheme":"ROR","value":"https://ror.org/03angcq70"},{"scheme":"OrgRef","value":"209935"},{"scheme":"FundRef","value":"501100024311"},{"scheme":"FundRef","value":"501100000855"},{"scheme":"FundRef","value":"501100020585"},{"scheme":"GRID","value":"grid.6572.6"}]}],"communities":[{"code":"uarctic","label":"UArctic","provenance":null},{"code":"netherlands","label":"Netherlands Research Portal","provenance":null},{"code":"eutopia","label":"EUTOPIA Open Research Portal","provenance":null}],"collectedFrom":[{"key":"eurocrisdris::ddb606710dacf8134d76a791c9a9fb1e","value":"University of Groningen Research Portal"},{"key":"opendoar____::1759e864edd6cb2200926b3a2f729dac","value":"Polish Platform of Medical Research"},{"key":"opendoar____::89fcd07f20b6785b92134bd6c1d0fa42","value":"Archivio Istituzionale della Ricerca (AperTO) - Università di Torino"},{"key":"openaire____::081b82f96300b6a6e3d282bad31cb6e2","value":"Crossref"},{"key":"opendoar____::8b6dd7db9af49e67306feb59a8bdc52c","value":"Europe PubMed Central"},{"key":"opendoar____::eda80a3d5b344bc40f3bc04f65b7a357","value":"PubMed Central"}],"instances":[{"pids":[{"scheme":"doi","value":"10.1016/j.ebiom.2026.106126"}],"license":"CC BY","accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":"gold"},"type":"Article","urls":["https://doi.org/10.1016/j.ebiom.2026.106126"],"publicationDate":"2026-02-01","refereed":"peerReviewed","hostedBy":{"key":"doajarticles::d7e8eea991edd05790a1f3fa548acdce","value":"EBioMedicine"},"collectedFrom":{"key":"openaire____::081b82f96300b6a6e3d282bad31cb6e2","value":"Crossref"}},{"pids":[{"scheme":"pmid","value":"41576621"},{"scheme":"pmc","value":"PMC12860258"}],"alternateIdentifiers":[{"scheme":"doi","value":"10.1016/j.ebiom.2026.106126"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":"gold"},"type":"Article","urls":["https://pubmed.ncbi.nlm.nih.gov/41576621"],"refereed":"nonPeerReviewed","hostedBy":{"key":"doajarticles::d7e8eea991edd05790a1f3fa548acdce","value":"EBioMedicine"},"collectedFrom":{"key":"opendoar____::8b6dd7db9af49e67306feb59a8bdc52c","value":"Europe PubMed Central"}},{"alternateIdentifiers":[{"scheme":"doi","value":"10.1016/j.ebiom.2026.106126"}],"license":"CC BY","accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Article","urls":["https://pmc.ncbi.nlm.nih.gov/articles/PMC12860258/","https://pubmed.ncbi.nlm.nih.gov/41576621/","https://doi.org/10.1016/j.ebiom.2026.106126"],"publicationDate":"2026-01-22","refereed":"nonPeerReviewed","hostedBy":{"key":"opendoar____::eda80a3d5b344bc40f3bc04f65b7a357","value":"PubMed Central"},"collectedFrom":{"key":"opendoar____::eda80a3d5b344bc40f3bc04f65b7a357","value":"PubMed Central"}},{"pids":[{"scheme":"handle","value":"11370/830993eb-eb48-4397-ac68-73c457c914f3"}],"alternateIdentifiers":[{"scheme":"doi","value":"10.1016/j.ebiom.2026.106126"}],"license":"CC BY NC ND","accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":"gold"},"type":"Article","urls":["https://hdl.handle.net/11370/830993eb-eb48-4397-ac68-73c457c914f3","https://research.rug.nl/en/publications/830993eb-eb48-4397-ac68-73c457c914f3","https://doi.org/10.1016/j.ebiom.2026.106126"],"publicationDate":"2026-02-01","refereed":"nonPeerReviewed","hostedBy":{"key":"doajarticles::d7e8eea991edd05790a1f3fa548acdce","value":"EBioMedicine"},"collectedFrom":{"key":"eurocrisdris::ddb606710dacf8134d76a791c9a9fb1e","value":"University of Groningen Research Portal"}},{"alternateIdentifiers":[{"scheme":"doi","value":"10.1016/j.ebiom.2026.106126"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":"gold"},"type":"Article","urls":["https://doi.org/10.1016/j.ebiom.2026.106126"],"publicationDate":"2026-01-01","refereed":"nonPeerReviewed","hostedBy":{"key":"doajarticles::d7e8eea991edd05790a1f3fa548acdce","value":"EBioMedicine"},"collectedFrom":{"key":"opendoar____::1759e864edd6cb2200926b3a2f729dac","value":"Polish Platform of Medical Research"}},{"pids":[{"scheme":"handle","value":"2318/2122411"}],"alternateIdentifiers":[{"scheme":"urn","value":"2-s2.0-105028403672"},{"scheme":"pmid","value":"41576621"},{"scheme":"doi","value":"10.1016/j.ebiom.2026.106126"}],"accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":null},"type":"Article","urls":["https://hdl.handle.net/2318/2122411","https://doi.org/10.1016/j.ebiom.2026.106126"],"publicationDate":"2026-01-01","refereed":"nonPeerReviewed","hostedBy":{"key":"opendoar____::89fcd07f20b6785b92134bd6c1d0fa42","value":"Archivio Istituzionale della Ricerca (AperTO) - Università di Torino"},"collectedFrom":{"key":"opendoar____::89fcd07f20b6785b92134bd6c1d0fa42","value":"Archivio Istituzionale della Ricerca (AperTO) - Università di Torino"}}],"links":[{"header":{"relationType":"resultProject","relationClass":"isProducedBy","relatedIdentifier":"corda_____he::c38637d43badadacec8bea9e3689b01f","relatedRecordType":"project","relationProvenance":"sysimport:actionset","trust":"0.91"},"collectedfrom":[{"dsId":"openaire____::3f264f93cf3b0cfc4ede188a6300455c","dsName":"CORDA - COmmon Research DAta Warehouse - Horizon Europe"}],"projectTitle":"Improving treatment efficacy in hypertension by biomarker-guided personalised decision support","code":"101095407","funding":{"funder":{"id":"ec__________::EC","shortname":"EC","name":"European Commission","jurisdiction":{"code":"EU","label":"European Union"},"pid":null},"level0":{"id":"ec__________::EC::HE","description":"Horizon Europe Framework Programme","name":"HE"},"level1":{"id":"ec__________::EC::HE::HORIZON-RIA","description":"HORIZON  Research and Innovation Actions","name":"HORIZON-RIA"},"level2":{"id":null,"description":null,"name":null}},"startDate":"2023-03-01","endDate":"2029-02-28"},{"header":{"relationType":"resultProject","relationClass":"isProducedBy","relatedIdentifier":"ukri________::7cc88f57292668ae35658b07571a291d","relatedRecordType":"project","relationProvenance":"sysimport:actionset","trust":"0.91"},"collectedfrom":[{"dsId":"openaire____::92ed35af5f7f859de570d1d2919c09a4","dsName":"UK Research and Innovation"}],"projectTitle":"Integrating innovative technologies for genotyping and phenotyping in stratified medicine","code":"MR/M009157/1","funding":{"funder":{"id":"ukri________::UKRI","shortname":"UKRI","name":"UK Research and Innovation","jurisdiction":{"code":"GB","label":"United Kingdom"},"pid":null},"level0":{"id":"ukri________::UKRI::MRC","description":"MRC","name":"MRC"},"level1":{"id":null,"description":null,"name":null},"level2":{"id":null,"description":null,"name":null}},"startDate":"2015-03-31","endDate":"2018-06-30"},{"header":{"relationType":"resultProject","relationClass":"isProducedBy","relatedIdentifier":"dfgf________::1e5e62235d094afd01cd56e65112fc63","relatedRecordType":"project","relationProvenance":"sysimport:actionset","trust":"0.91"},"collectedfrom":[{"dsId":"openaire____::513d203da49f316ec241afa087643a02","dsName":"Deutsche Forschungsgemeinschaft"}],"projectTitle":"unidentified","code":"unidentified","funding":{"funder":{"id":"dfgf________::DFG","shortname":"DFG","name":"Deutsche Forschungsgemeinschaft","jurisdiction":{"code":"DE","label":"Germany"},"pid":null},"level0":{"id":null,"description":null,"name":null},"level1":{"id":null,"description":null,"name":null},"level2":{"id":null,"description":null,"name":null}}},{"header":{"relationType":"resultProject","relationClass":"isProducedBy","relatedIdentifier":"ukri________::d20b8afe4a54b76f72a0713fe5c09bc3","relatedRecordType":"project","relationProvenance":"sysimport:actionset","trust":"0.91"},"collectedfrom":[{"dsId":"openaire____::92ed35af5f7f859de570d1d2919c09a4","dsName":"UK Research and Innovation"}],"projectTitle":"Steroid profiling as a biomarker tool in the diagnosis and monitoring of adrenal tumours","code":"G0801473","funding":{"funder":{"id":"ukri________::UKRI","shortname":"UKRI","name":"UK Research and Innovation","jurisdiction":{"code":"GB","label":"United Kingdom"},"pid":null},"level0":{"id":"ukri________::UKRI::MRC","description":"MRC","name":"MRC"},"level1":{"id":null,"description":null,"name":null},"level2":{"id":null,"description":null,"name":null}},"startDate":"2009-03-01","endDate":"2012-02-29"}],"otherTitles":null,"inDiamondJournal":false,"green":true,"isGreen":true,"isInDiamondJournal":false}