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The fellowship code is LCF/BQ/DI19/11730048) and financed L.M.’s work. In addition, G.D., M.V.-V. and L.M. were supported by the Human Brain Project Specific Grant Agreement 3 Grant agreement no. 945539 financed by the European Commission and by the Spanish Research Project ref. PID2019-105772GB-I00/AEI/10.13039/501100011033, financed by the Spanish Ministry of Science, Innovation and Universities (MCIU), State Research Agency (AEI). This last institution also financed M.V.-V through the grant/award number PID2020-119072RA-I00/AEI/10.13039/501100011033. G.D. was supported by the project NEurological MEchanismS of Injury, and Sleep-like cellular dynamics (NEMESIS) (ref. 101071900) funded by the EU ERC Synergy Horizon Europe; by the NODYN Project PID2022-136216NBI00 funded by MICIU/AEI/10.13039/501100011033 and by ‘ERDF A way of making Europe,’ ERDF, EU; by the AGAUR research support grant (ref. 2021 SGR 00917) funded by the Department of Research and Universities of the Generalitat of Catalunya; and by the project eBRAIN-Health—Actionable Multilevel Health Data (ID 101058516), funded by the EU Horizon Europe. A.L.-G. was supported by Swiss National Science Foundation Sinergia grant no. 170873. L.A.E. was supported by a research grant of University of Lausanne, Switzerland. L.A. was supported by a fellowship of the Adrian and Simone Frutiger Foundation and from Carigest Foundation. P.K. was supported by a fellowship from the Adrian and Simone Frutiger Foundation. Y.A.-G. and P.H. were financially supported by Swiss National Science Foundation grant no. 320030-197787.","Functional brain scans have shown that connectivity alterations are strongly associated with the first episode of psychosis, yet it is not well understood whether these alterations vary with the clinical status of patients at the time of scanning. This cross-sectional study aimed to identify brain connectivity properties that differentiate remitting and non-remitting early psychosis (EP) patients from healthy controls and to explore the mechanisms underlying these differences. To this end, we analyzed resting-state fMRI and DSI data from 88 EP patients categorized by their remission ability after the first episode of psychosis. We focused on differences between stage III remitting–relapsing (EP3R) and stage III non-remitting (EP3NR) patients. 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