{"authors":[{"id":"orcid_______::d410fbdebeb4d321eddc9e9af1a35731","fullName":"Boris Schmitz","name":"Boris","surname":"Schmitz","rank":1,"pid":{"id":{"scheme":"orcid","value":"0000-0001-7041-7424"},"provenance":null}},{"id":"orcid_______::8d5630db2b862e493636bc4cc0bc2c85","fullName":"René Garbsch","name":"René","surname":"Garbsch","rank":2,"pid":{"id":{"scheme":"orcid","value":"0000-0001-7428-5692"},"provenance":null}},{"id":null,"fullName":"Hendrik Schäfer","name":"Hendrik","surname":"Schäfer","rank":3,"pid":null},{"id":null,"fullName":"Christian Bär","name":"Christian","surname":"Bär","rank":4,"pid":null},{"id":"orcid_______::2e22b1e395428a6d43d87d106b2eadfa","fullName":"Shambhabi Chatterjee","name":"Shambhabi","surname":"Chatterjee","rank":5,"pid":{"id":{"scheme":"orcid","value":"0000-0001-5978-3562"},"provenance":null}},{"id":null,"fullName":"Gabriela Riemekasten","name":"Gabriela","surname":"Riemekasten","rank":6,"pid":null},{"id":null,"fullName":"Kai Schulze-Forster","name":"Kai","surname":"Schulze-Forster","rank":7,"pid":null},{"id":null,"fullName":"Harald Heidecke","name":"Harald","surname":"Heidecke","rank":8,"pid":null},{"id":"orcid_______::050c765a0a3d49cf20b596b380916d55","fullName":"Christoph Schultheiß","name":"Christoph","surname":"Schultheiß","rank":9,"pid":{"id":{"scheme":"orcid","value":"0000-0001-9789-5776"},"provenance":null}},{"id":"orcid_______::af3a1185f208a56ea457f77957b2e2c4","fullName":"Mascha Binder","name":"Mascha","surname":"Binder","rank":10,"pid":{"id":{"scheme":"orcid","value":"0000-0003-0663-3004"},"provenance":null}},{"id":null,"fullName":"Frank C. Mooren","name":"Frank C.","surname":"Mooren","rank":11,"pid":null}],"openAccessColor":"hybrid","publiclyFunded":false,"eoscIfGuidelines":null,"type":"publication","language":{"code":"eng","label":"English"},"countries":null,"subjects":[{"subject":{"scheme":"keyword","value":"Male"},"provenance":null},{"subject":{"scheme":"keyword","value":"Adult"},"provenance":null},{"subject":{"scheme":"keyword","value":"SARS-CoV-2"},"provenance":null},{"subject":{"scheme":"keyword","value":"Receptors, Antigen, T-Cell"},"provenance":null},{"subject":{"scheme":"keyword","value":"COVID-19"},"provenance":null},{"subject":{"scheme":"keyword","value":"Receptors, Antigen, B-Cell"},"provenance":null},{"subject":{"scheme":"keyword","value":"Middle Aged"},"provenance":null},{"subject":{"scheme":"keyword","value":"Receptors, G-Protein-Coupled"},"provenance":null},{"subject":{"scheme":"FOS","value":"03 medical and health sciences"},"provenance":null},{"subject":{"scheme":"FOS","value":"0302 clinical medicine"},"provenance":null},{"subject":{"scheme":"keyword","value":"Autonomic Nervous System Diseases"},"provenance":null},{"subject":{"scheme":"keyword","value":"Heart Rate"},"provenance":null},{"subject":{"scheme":"keyword","value":"Humans"},"provenance":null},{"subject":{"scheme":"keyword","value":"Female"},"provenance":null},{"subject":{"scheme":"keyword","value":"Autoantibodies"},"provenance":null},{"subject":{"scheme":"keyword","value":"Aged"},"provenance":null}],"mainTitle":"Autonomic dysfunction and vasoregulation in long COVID-19 are linked to anti-GPCR autoantibodies","subTitle":null,"descriptions":["Severe acute respiratory syndrome coronavirus 2-triggered autoantibodies (AABs) targeting G protein-coupled receptors have been suggested to contribute to the post-acute sequelae of coronavirus disease 2019 (or post-COVID-19 syndrome [PCS]).We sought to characterize AABs involved in autonomic dysfunction such as rhythm control and vasoregulation in patients with PCS and profile the peripheral B- and T-cell receptor (BCR/TCR) architecture to identify immunogenetic imprints of autoimmunity.Anti-G protein-coupled receptor AABs were characterized in patients with PCS with known alteration in autonomic nervous system functions assessed by heart rate variability. Adaptive immune receptor repertoire sequencing was used to profile peripheral BCR and TCR architecture. Patients with COVID-19 with severe or moderate acute disease, after recovery, and prepandemic healthy individuals served as controls. Cardio- and vasoactive effects of AABs were analyzed using 24-hour and exercise test blood pressure measurements. The direct effect of AABs on electromechanical coupling was tested in human-induced pluripotent stem cell cardiomyocytes.AABs including autoantibody against angiotensin II receptor type 1/2, autoantibody against adrenoceptor beta 1/2, autoantibody against muscarinic acetylcholine receptor M1/M3, and autoantibody against C-X-C motif chemokine receptor 3 (CXCR3ab) were associated with heart rate variability alterations. Analysis of the broad BCR repertoire metrics revealed high similarity between patients with PCS and healthy controls for clonality and diversity measures. The level of somatic hypermutation as proxy for antigen experience was equal to that of healthy controls. Elevated CXCR3ab levels were linked to higher 24-hour mean arterial pressure, whereas patients with elevated autoantibody against muscarinic acetylcholine receptor M1 and CXCR3ab levels showed higher blood pressure during stress tests. AABs had no effect on beat frequency and amplitude of cardiomyocyte contraction in vitro.These findings suggest that AABs play a modulatory role in sympathetic nervous system-mediated regulation of cardiac rhythm and vascular function in PCS. AAB levels did not correlate with BCR and TCR repertoire metrics or T-cell receptor beta variable gene usage."],"publicationDate":"2026-03-01","publisher":"Elsevier BV","embargoEndDate":null,"sources":["Crossref"],"formats":null,"contributors":null,"coverages":null,"bestAccessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/"},"container":{"name":"Journal of Allergy and Clinical Immunology","issnPrinted":"0091-6749","issnOnline":null,"issnLinking":null,"ep":"738.e7","iss":null,"sp":"722","vol":"157","edition":null,"conferencePlace":null,"conferenceDate":null},"documentationUrls":null,"codeRepositoryUrl":null,"programmingLanguage":null,"contactPeople":null,"contactGroups":null,"tools":null,"size":null,"version":null,"geoLocations":null,"id":"doi_dedup___::32437a73aecf7550a29dc90ae3219eaa","originalIds":["S0091674925011285","10.1016/j.jaci.2025.10.034","50|doiboost____|32437a73aecf7550a29dc90ae3219eaa","41274384"],"pids":[{"scheme":"doi","value":"10.1016/j.jaci.2025.10.034"},{"scheme":"pmid","value":"41274384"}],"dateOfCollection":null,"lastUpdateTimeStamp":null,"indicators":{"citationImpact":{"citationCount":5.0,"influence":2.3873061E-9,"popularity":6.0299503E-9,"impulse":5.0,"citationClass":"C5","influenceClass":"C5","impulseClass":"C4","popularityClass":"C4"}},"projects":[{"id":"corda__h2020::0dbb542bd310dca93e251b3e1a7190f7","code":"101017424","acronym":"TIMELY","title":"A patient-centered early risk prediction, prevention, and intervention platform to support the continuum of care in coronary artery disease (CAD) using eHealth and artificial intelligence","funder":"European Commission","pids":[{"scheme":"doi","value":"10.3030/101017424"}]},{"id":"dfgf________::1e5e62235d094afd01cd56e65112fc63","code":"unidentified","acronym":null,"title":"unidentified","funder":"Deutsche Forschungsgemeinschaft","pids":null}],"organizations":[{"legalName":"University Hospital Schleswig-Holstein","acronym":"UKSH","id":"openorgs____::eca6a87891b1a73a5a8f752219c968fd","pids":[{"scheme":"Wikidata","value":"Q2496401"},{"scheme":"wikidata","value":"Q30279564"},{"scheme":"Wikidata","value":"Q30279564"},{"scheme":"wikidata","value":"Q2496401"},{"scheme":"ROR","value":"https://ror.org/01tvm6f46"},{"scheme":"GRID","value":"grid.412468.d"},{"scheme":"ISNI","value":"0000000406462097"},{"scheme":"OrgReg","value":"DE2013"},{"scheme":"PIC","value":"999845349"}]},{"legalName":"Witten/Herdecke University","acronym":"UW/H","id":"openorgs____::f89167716655b5456ab945154646b77a","pids":[{"scheme":"OrgRef","value":"30860981"},{"scheme":"wikidata","value":"Q314305"},{"scheme":"ROR","value":"https://ror.org/00yq55g44"},{"scheme":"ISNI","value":"0000000090246397"},{"scheme":"OrgReg","value":"DE0083"},{"scheme":"Wikidata","value":"Q314305"},{"scheme":"mag_id","value":"155976169"},{"scheme":"GRID","value":"grid.412581.b"},{"scheme":"fundref","value":"501100024068"}]},{"legalName":"Fraunhofer Institute for Toxicology and Experimental Medicine","acronym":"ITEM","id":"openorgs____::6826001959ceaead5a165e38efc5f5fa","pids":[{"scheme":"Wikidata","value":"Q1452035"},{"scheme":"ISNI","value":"0000000091919864"},{"scheme":"ROR","value":"https://ror.org/02byjcr11"},{"scheme":"GRID","value":"grid.418009.4"},{"scheme":"wikidata","value":"Q1452035"}]},{"legalName":"Fraunhofer Society","acronym":"FHG","id":"openorgs____::76681f01bcfcc1ff3405bed86eea99b2","pids":[{"scheme":"RRID","value":"RRID:nlx_157956"},{"scheme":"PIC","value":"999659400"},{"scheme":"PIC","value":"999598290"},{"scheme":"PIC","value":"999984059"},{"scheme":"RRID","value":"RRID:SCR_011231"},{"scheme":"ISNI","value":"0000000092613939"},{"scheme":"FundRef","value":"501100003185"},{"scheme":"fundref","value":"501100003185"},{"scheme":"OrgReg","value":"DE1053"},{"scheme":"PIC","value":"999934589"},{"scheme":"OrgRef","value":"197440"},{"scheme":"GRID","value":"grid.4561.6"},{"scheme":"wikidata","value":"Q161057"},{"scheme":"ROR","value":"https://ror.org/05hkkdn48"},{"scheme":"mag_id","value":"4923324"},{"scheme":"Wikidata","value":"Q161057"}]},{"legalName":"Hannover Medical School","acronym":"MHH","id":"openorgs____::4757acbca48c751a62c335e0b3e49d3d","pids":[{"scheme":"ROR","value":"https://ror.org/00f2yqf98"},{"scheme":"GRID","value":"grid.10423.34"},{"scheme":"mag_id","value":"34809795"},{"scheme":"RRID","value":"RRID:SCR_011266"},{"scheme":"PIC","value":"999878426"},{"scheme":"ISNI","value":"0000000123428921"},{"scheme":"Wikidata","value":"Q911561"},{"scheme":"OrgReg","value":"DE0062"},{"scheme":"ISNI","value":"0000000095299877"},{"scheme":"FundRef","value":"501100005624"},{"scheme":"OrgRef","value":"11085502"},{"scheme":"wikidata","value":"Q911561"},{"scheme":"fundref","value":"501100005624"}]},{"legalName":"University Hospital of Basel","acronym":"USB","id":"openorgs____::08f53f338acf0521ace2c500c56caba3","pids":[{"scheme":"Wikidata","value":"Q1689257"},{"scheme":"ROR","value":"https://ror.org/04k51q396"},{"scheme":"OrgRef","value":"40190980"},{"scheme":"FundRef","value":"100016015"},{"scheme":"GRID","value":"grid.410567.1"},{"scheme":"fundref","value":"100016015"},{"scheme":"PIC","value":"999898602"},{"scheme":"wikidata","value":"Q1689257"},{"scheme":"mag_id","value":"2802542264"},{"scheme":"ISNI","value":"000000011882505X"}]}],"communities":[{"code":"covid-19","label":"Corona Virus Disease","provenance":null}],"collectedFrom":[{"key":"openaire____::081b82f96300b6a6e3d282bad31cb6e2","value":"Crossref"},{"key":"opendoar____::8b6dd7db9af49e67306feb59a8bdc52c","value":"Europe PubMed Central"}],"instances":[{"pids":[{"scheme":"doi","value":"10.1016/j.jaci.2025.10.034"}],"license":"CC BY","accessRight":{"code":"c_abf2","label":"OPEN","scheme":"http://vocabularies.coar-repositories.org/documentation/access_rights/","openAccessRoute":"hybrid"},"type":"Article","urls":["https://doi.org/10.1016/j.jaci.2025.10.034"],"publicationDate":"2026-03-01","refereed":"peerReviewed","hostedBy":{"key":"issn___print::be7c90fabd506d73f6a389b377632ceb","value":"Journal of Allergy and Clinical Immunology"},"collectedFrom":{"key":"openaire____::081b82f96300b6a6e3d282bad31cb6e2","value":"Crossref"}},{"pids":[{"scheme":"pmid","value":"41274384"}],"alternateIdentifiers":[{"scheme":"doi","value":"10.1016/j.jaci.2025.10.034"}],"type":"Article","urls":["https://pubmed.ncbi.nlm.nih.gov/41274384"],"publicationDate":"2026-03-07","refereed":"nonPeerReviewed","hostedBy":{"key":"openaire____::55045bd2a65019fd8e6741a755395c8c","value":"Unknown Repository"},"collectedFrom":{"key":"opendoar____::8b6dd7db9af49e67306feb59a8bdc52c","value":"Europe PubMed Central"}}],"links":[{"header":{"relationType":"resultProject","relationClass":"isProducedBy","relatedIdentifier":"corda__h2020::0dbb542bd310dca93e251b3e1a7190f7","relatedRecordType":"project","relationProvenance":"sysimport:actionset","trust":"0.91"},"collectedfrom":[{"dsId":"openaire____::a55eb91348674d853191f4f4fd73d078","dsName":"CORDA - COmmon Research DAta Warehouse - Horizon 2020"}],"projectTitle":"A patient-centered early risk prediction, prevention, and intervention platform to support the continuum of care in coronary artery disease (CAD) using eHealth and artificial intelligence","code":"101017424","funding":{"funder":{"id":"ec__________::EC","shortname":"EC","name":"European Commission","jurisdiction":{"code":"EU","label":"European Union"},"pid":null},"level0":{"id":"ec__________::EC::H2020","description":"Horizon 2020 Framework Programme","name":"H2020"},"level1":{"id":"ec__________::EC::H2020::RIA","description":"Research and Innovation action","name":"RIA"},"level2":{"id":null,"description":null,"name":null}},"startDate":"2021-01-01","endDate":"2025-03-31"},{"header":{"relationType":"resultProject","relationClass":"isProducedBy","relatedIdentifier":"dfgf________::1e5e62235d094afd01cd56e65112fc63","relatedRecordType":"project","relationProvenance":"sysimport:actionset","trust":"0.91"},"collectedfrom":[{"dsId":"openaire____::513d203da49f316ec241afa087643a02","dsName":"Deutsche Forschungsgemeinschaft"}],"projectTitle":"unidentified","code":"unidentified","funding":{"funder":{"id":"dfgf________::DFG","shortname":"DFG","name":"Deutsche Forschungsgemeinschaft","jurisdiction":{"code":"DE","label":"Germany"},"pid":null},"level0":{"id":null,"description":null,"name":null},"level1":{"id":null,"description":null,"name":null},"level2":{"id":null,"description":null,"name":null}}}],"otherTitles":null,"inDiamondJournal":false,"green":false,"isGreen":false,"isInDiamondJournal":false}