{"header":{"numFound":35434,"maxScore":1.0,"queryTime":24,"page":1,"pageSize":10},"results":[{"id":"corda__h2020::0000180e94707c0d90547614c17076bf","code":"752491","acronym":"metabolicomp","title":"Computational dynamics studies of drug metabolism by P450 enzymes","websiteUrl":null,"startDate":"2017-06-21","endDate":"2019-06-20","callIdentifier":"H2020-MSCA-IF-2016","keywords":null,"openAccessMandateForPublications":true,"openAccessMandateForDataset":false,"subjects":["Individual Fellowships"],"fundings":[{"shortName":"EC","name":"European Commission","jurisdiction":"EU","fundingStream":{"id":"EC::H2020::MSCA-IF-EF-ST","description":"Horizon 2020 Framework Programme - Standard European Fellowships"}}],"summary":"Cytochrome P450 enzymes monitor the metabolism of many drugs and small-molecules, as well as selectively catalyze hydrocarbon substrates for application in biotechnology. Drug-drug interactions are critical to the management of safe and effective pharmaceutical treatments. Thus, it is important to better understand the biological functions and activities of P450 enzymes not only to maximize their clinical significance but also to develop broader application in other fields, such as biofuel. There has been significant investment in computational and theoretical studies of P450 enzymes; however, there remains a need for further dynamical calculations to better explore the involvement of the enzyme active site in competing pathways leading to various products. This project aims to determine the role of P450 enzyme in alcohol and alkene formations, compare and contrast heme and non-heme Fe-containing active sites, and model the effect of enzyme environment, using quantum mechanical calculations and inherent dynamics via quasi-classical simulation. The results from this study will help advance the field of computational modeling and its application in biologically important systems.","granted":{"currency":"EUR","totalCost":183455.0,"fundedAmount":183455.0},"h2020Programmes":null,"funding":{"funder":{"id":"ec__________::EC","shortname":"EC","name":"European Commission","jurisdiction":{"code":"EU","label":"European Union"},"pid":null},"level0":{"id":"ec__________::EC::H2020","description":"Horizon 2020 Framework Programme","name":"H2020"},"level1":{"id":"ec__________::EC::H2020::MSCA-IF-EF-ST","description":"Standard European Fellowships","name":"MSCA-IF-EF-ST"},"level2":null},"links":[{"header":{"relationType":"projectOrganization","relationClass":"hasParticipant","relatedIdentifier":"pending_org_::77cd584c222abe3970e2bd23b46df83c","relatedRecordType":"organization","relationProvenance":"sysimport:crosswalk:entityregistry","trust":"0.900"},"title":null,"websiteurl":"http://www.ox.ac.uk","pid":[{"value":"999984350","typeCode":"PIC","typeLabel":"Participant Identification Code"}],"collectedfrom":[{"dsId":"openaire____::0362fcdb3076765d9c0041ad331553e8","dsName":"OpenOrgs Database"}],"author":null,"description":null,"dateofacceptance":null,"publisher":null,"codeRepositoryUrl":null,"resulttype":null,"instances":null,"officialname":null,"datasourcetype":null,"datasourcetypeui":null,"openairecompatibility":null,"legalname":"THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD","legalshortname":"UOXF","country":{"code":"GB","label":"United Kingdom"},"projectTitle":null,"code":null,"acronym":null,"contracttype":null,"funding":null,"validationDate":null,"startDate":null,"endDate":null,"givenName":null,"familyName":null,"personRoleInProject":null,"declaredAffiliation":null,"affiliationsTimeline":null}]},{"id":"corda__h2020::0001181bf1ad8f82dcf59c7c18343bd5","code":"752608","acronym":"HT PHOTO DB","title":"High throughput computing for accelerated photovoltaic material discovery: From material\ndatabase to the new generation of photovoltaic materials.","websiteUrl":null,"startDate":"2018-04-01","endDate":"2020-05-31","callIdentifier":"H2020-MSCA-IF-2016","keywords":null,"openAccessMandateForPublications":true,"openAccessMandateForDataset":false,"subjects":["Individual Fellowships"],"fundings":[{"shortName":"EC","name":"European Commission","jurisdiction":"EU","fundingStream":{"id":"EC::H2020::MSCA-IF-EF-ST","description":"Horizon 2020 Framework Programme - Standard European Fellowships"}}],"summary":"This proposal combines synergistically the predictive power of quantum mechanical calculations with a high throughput framework for the accelerated photovoltaic material discovery. The main objective of the project is the creation of a material database that contains no crystalline-complex materials, which can be potential candidate for the development of a new generation of photovoltaic material. The robustness of the project is reinforced by the secondment of Onyx solar which will synthesis and characterize the most promising candidates to validate the methodology and optimize the process. The collaboration between ICCRAM researchers and facilities and the experience of the fellow in this multidisciplinary field guarantee the ideal conditions for the success of the research and the development of new methodologies, infrastructures and knowledge that are highly linked to the roadmap described in Horizon 2020","granted":{"currency":"EUR","totalCost":158122.0,"fundedAmount":158122.0},"h2020Programmes":null,"funding":{"funder":{"id":"ec__________::EC","shortname":"EC","name":"European Commission","jurisdiction":{"code":"EU","label":"European Union"},"pid":null},"level0":{"id":"ec__________::EC::H2020","description":"Horizon 2020 Framework Programme","name":"H2020"},"level1":{"id":"ec__________::EC::H2020::MSCA-IF-EF-ST","description":"Standard European Fellowships","name":"MSCA-IF-EF-ST"},"level2":null},"links":[{"header":{"relationType":"projectOrganization","relationClass":"hasParticipant","relatedIdentifier":"openorgs____::5885c08526347ed38859d7af11ac6f0c","relatedRecordType":"organization","relationProvenance":"sysimport:crosswalk:entityregistry","trust":"0.900"},"title":null,"websiteurl":"http://www.ubu.es/es/english-information","pid":[{"value":"Q1510657","typeCode":"wikidata","typeLabel":"wikidata"},{"value":"15214203","typeCode":"OrgRef","typeLabel":"OrgRef"},{"value":"https://ror.org/049da5t36","typeCode":"ROR","typeLabel":"ROR"},{"value":"46176106","typeCode":"mag_id","typeLabel":"Microsoft Academic Graph Identifier"},{"value":"998959642","typeCode":"PIC","typeLabel":"Participant Identification Code"},{"value":"ES0029","typeCode":"OrgReg","typeLabel":"OrgReg"},{"value":"100019629","typeCode":"fundref","typeLabel":"fundref"},{"value":"Q1510657","typeCode":"Wikidata","typeLabel":"Wikidata"},{"value":"100019629","typeCode":"FundRef","typeLabel":"FundRef"},{"value":"0000000085691592","typeCode":"ISNI","typeLabel":"International Standard Name Identifier"},{"value":"grid.23520.36","typeCode":"GRID","typeLabel":"GRID"}],"collectedfrom":[{"dsId":"openaire____::0362fcdb3076765d9c0041ad331553e8","dsName":"OpenOrgs Database"}],"author":null,"description":null,"dateofacceptance":null,"publisher":null,"codeRepositoryUrl":null,"resulttype":null,"instances":null,"officialname":null,"datasourcetype":null,"datasourcetypeui":null,"openairecompatibility":null,"legalname":"University of Burgos","legalshortname":"UBU","country":{"code":"ES","label":"Spain"},"projectTitle":null,"code":null,"acronym":null,"contracttype":null,"funding":null,"validationDate":null,"startDate":null,"endDate":null,"givenName":null,"familyName":null,"personRoleInProject":null,"declaredAffiliation":null,"affiliationsTimeline":null},{"header":{"relationType":"projectOrganization","relationClass":"hasParticipant","relatedIdentifier":"openorgs____::5665ec851e301a1f816ee0be3e98757b","relatedRecordType":"organization","relationProvenance":"sysimport:crosswalk:entityregistry","trust":"0.900"},"title":null,"websiteurl":"http://www.us.es/eng","pid":[{"value":"999862518","typeCode":"PIC","typeLabel":"Participant Identification Code"},{"value":"0000000121681229","typeCode":"ISNI","typeLabel":"International Standard Name Identifier"},{"value":"247917","typeCode":"OrgRef","typeLabel":"OrgRef"},{"value":"Q1229996","typeCode":"wikidata","typeLabel":"wikidata"},{"value":"https://ror.org/03yxnpp24","typeCode":"ROR","typeLabel":"ROR"},{"value":"Q1229996","typeCode":"Wikidata","typeLabel":"Wikidata"},{"value":"100009042","typeCode":"fundref","typeLabel":"fundref"},{"value":"grid.9224.d","typeCode":"GRID","typeLabel":"GRID"},{"value":"100009042","typeCode":"FundRef","typeLabel":"FundRef"},{"value":"ES0009","typeCode":"OrgReg","typeLabel":"OrgReg"},{"value":"79238269","typeCode":"mag_id","typeLabel":"Microsoft Academic Graph Identifier"}],"collectedfrom":[{"dsId":"openaire____::0362fcdb3076765d9c0041ad331553e8","dsName":"OpenOrgs Database"}],"author":null,"description":null,"dateofacceptance":null,"publisher":null,"codeRepositoryUrl":null,"resulttype":null,"instances":null,"officialname":null,"datasourcetype":null,"datasourcetypeui":null,"openairecompatibility":null,"legalname":"University of Seville","legalshortname":"University of Seville","country":{"code":"ES","label":"Spain"},"projectTitle":null,"code":null,"acronym":null,"contracttype":null,"funding":null,"validationDate":null,"startDate":null,"endDate":null,"givenName":null,"familyName":null,"personRoleInProject":null,"declaredAffiliation":null,"affiliationsTimeline":null}]},{"id":"corda__h2020::000235557658069f5638a01bd46a72c8","code":"893032","acronym":"RightsLab","title":"Towards Transnational Labour Rights? Temporary Work Agencies and Third Country National Workers in the EU.","websiteUrl":null,"startDate":"2021-01-11","endDate":"2024-01-10","callIdentifier":"H2020-MSCA-IF-2019","keywords":null,"openAccessMandateForPublications":true,"openAccessMandateForDataset":false,"subjects":["Individual Fellowships"],"fundings":[{"shortName":"EC","name":"European Commission","jurisdiction":"EU","fundingStream":{"id":"EC::H2020::MSCA-IF-EF-CAR","description":"Horizon 2020 Framework Programme - Career Restart panel"}}],"summary":"The last two decades have seen the EU grappling with a direct conflict of interests; the securitization of its external borders and the demand for a low-cost flexible workforce which in various sectors of the economy, has been increasingly occupied by migrants. Employment of third country nationals (TCNs) through temporary work agencies (TWAs) became a common solution to allow for the smooth supply of workers both in core EU member states, and in Central and Eastern Europe (CEE) region, which is in itself effected by considerable emigration and labour mobility. RightsLab will look into the employment conditions of transnational workers employed through TWAs and ask: how can we develop mechanisms of effective transnational labour rights protection for agency workers? It will provide empirically grounded research into the employment of Ukrainian workers in two CEE countries – Poland and Hungary plus Italy. Both Poland and Hungary, recently has become a laboratory for TWA forms of flexible employment, and Ukrainians represent a large segment of the TCN workers there. Italy – a key destination country for Ukrainian migrants since the late 1990s – offers an important perspective into female employment.The novelty of RightsLab’s contribution is threefold; 1) existing research on the TWAs predominantly focuses on registering labour rights violations: RightsLab makes a step further by exploring the possibilities of creating better mechanisms for cross-border labour rights protection; 2) methodologically, RightsLab combines several qualitative methods, and takes an engaged, participatory stance, actively searching and connecting various participants of the research for a possible social dialogue; 3) by focusing on various levels (national ( labour inspectorates), meso (trade unions, workers’ associations, NGOs) and local (TWAs and workers themselves)) it provides a multidimensional picture of emerging transnational employment regimes and transitional labour struggles.","granted":{"currency":"EUR","totalCost":275210.0,"fundedAmount":275210.0},"h2020Programmes":null,"funding":{"funder":{"id":"ec__________::EC","shortname":"EC","name":"European Commission","jurisdiction":{"code":"EU","label":"European Union"},"pid":null},"level0":{"id":"ec__________::EC::H2020","description":"Horizon 2020 Framework Programme","name":"H2020"},"level1":{"id":"ec__________::EC::H2020::MSCA-IF-EF-CAR","description":"Career Restart panel","name":"MSCA-IF-EF-CAR"},"level2":null},"links":[{"header":{"relationType":"projectOrganization","relationClass":"hasParticipant","relatedIdentifier":"openorgs____::d6ddbed2807becaf5b096013ba158c9b","relatedRecordType":"organization","relationProvenance":"sysimport:crosswalk:entityregistry","trust":"0.900"},"title":null,"websiteurl":"https://www.unipd.it/en/","pid":[{"value":"RRID:SCR_006374","typeCode":"RRID","typeLabel":"Research Resource Identifier"},{"value":"501100019106","typeCode":"fundref","typeLabel":"fundref"},{"value":"https://ror.org/00240q980","typeCode":"ROR","typeLabel":"ROR"},{"value":"501100003500","typeCode":"fundref","typeLabel":"fundref"},{"value":"IT0050","typeCode":"OrgReg","typeLabel":"OrgReg"},{"value":"138689650","typeCode":"mag_id","typeLabel":"Microsoft Academic Graph Identifier"},{"value":"501100015490","typeCode":"FundRef","typeLabel":"FundRef"},{"value":"501100019106","typeCode":"FundRef","typeLabel":"FundRef"},{"value":"501100015490","typeCode":"fundref","typeLabel":"fundref"},{"value":"grid.5608.b","typeCode":"GRID","typeLabel":"GRID"},{"value":"501100003500","typeCode":"FundRef","typeLabel":"FundRef"},{"value":"378253","typeCode":"OrgRef","typeLabel":"OrgRef"},{"value":"https://ror.org/00240q980","typeCode":"ROR","typeLabel":"ROR"},{"value":"9308","typeCode":"RingGold","typeLabel":"RingGold"},{"value":"Q193510","typeCode":"wikidata","typeLabel":"wikidata"},{"value":"Q193510","typeCode":"Wikidata","typeLabel":"Wikidata"},{"value":"999995602","typeCode":"PIC","typeLabel":"Participant Identification Code"},{"value":"0000000417573470","typeCode":"ISNI","typeLabel":"International Standard Name Identifier"},{"value":"RRID:nlx_49809","typeCode":"RRID","typeLabel":"Research Resource Identifier"}],"collectedfrom":[{"dsId":"openaire____::0362fcdb3076765d9c0041ad331553e8","dsName":"OpenOrgs Database"}],"author":null,"description":null,"dateofacceptance":null,"publisher":null,"codeRepositoryUrl":null,"resulttype":null,"instances":null,"officialname":null,"datasourcetype":null,"datasourcetypeui":null,"openairecompatibility":null,"legalname":"University of Padua","legalshortname":"UNIPD","country":{"code":"IT","label":"Italy"},"projectTitle":null,"code":null,"acronym":null,"contracttype":null,"funding":null,"validationDate":null,"startDate":null,"endDate":null,"givenName":null,"familyName":null,"personRoleInProject":null,"declaredAffiliation":null,"affiliationsTimeline":null}]},{"id":"corda__h2020::0005513c19eabb488a6ece83ca6dc57a","code":"101029234","acronym":"SaRe-DiGT","title":"Safety and Resilience through Digital Practices: A Participatory Study with Women at the Intersection of Gender-Based Violence and Immigration in Norway","websiteUrl":null,"startDate":"2022-09-01","endDate":"2024-08-31","callIdentifier":"H2020-MSCA-IF-2020","keywords":null,"openAccessMandateForPublications":true,"openAccessMandateForDataset":false,"subjects":["Individual Fellowships"],"fundings":[{"shortName":"EC","name":"European Commission","jurisdiction":"EU","fundingStream":{"id":"EC::H2020::MSCA-IF-EF-ST","description":"Horizon 2020 Framework Programme - Standard European Fellowships"}}],"summary":"Rahaf Mohammed, an 18-year-old Saudi woman who was subjected to domestic violence, utilized social media to make her voice heard by foreign authorities. Via this ‘digital’ call for help, she successfully escaped violence. The internationally recognized #metoo movement became active on social media enabling women victims of gender-based violence (GBV) to seek justice and healing. While these examples show how digital technologies can allow individuals to exercise their agency and communicate their voices against violence, the existing academic studies in the field of GBV have yet to discuss the empowering outcomes of digital technology use for and by victims/survivors.  By addressing this gap, SaRe-DiGT aims to uncover the potentialities of digital technologies in enhancing victims'/survivors’ physical and emotional safety against violence. I particularly focus on the patterns and practices of digital technology use by immigrant women who have experiences of GBV. Considering the numerous barriers that immigrant women face while seeking safety from violence, SaRe-DiGT stresses on the instrumental use of digital technologies as a practical resource for information, communication, and mobilization to overcome violence. The project includes three phases: i) participatory focus groups, to identify and examine the opportunities enabled by digital technology use in women’s lives to navigate their ways towards safety and resilience from violence; ii) digital storytelling workshops, to co-develop resilience-promoting practices enabled by the creative use of digital technologies; and iii) website designing workshops, to co-design an online initiative as a practical digital resource to assist immigrant women in their efforts to reach safety and build resilience. In achieving these objectives, SaRe-DiGT will provide unique research-based knowledge and solutions to create transformative technology-facilitated strategies to combat violence among immigrant communities in Europe.","granted":{"currency":"EUR","totalCost":214159.0,"fundedAmount":214159.0},"h2020Programmes":null,"funding":{"funder":{"id":"ec__________::EC","shortname":"EC","name":"European Commission","jurisdiction":{"code":"EU","label":"European Union"},"pid":null},"level0":{"id":"ec__________::EC::H2020","description":"Horizon 2020 Framework Programme","name":"H2020"},"level1":{"id":"ec__________::EC::H2020::MSCA-IF-EF-ST","description":"Standard European Fellowships","name":"MSCA-IF-EF-ST"},"level2":null},"links":[{"header":{"relationType":"projectOrganization","relationClass":"hasParticipant","relatedIdentifier":"openorgs____::96554199369af517bbdd265ae287c19a","relatedRecordType":"organization","relationProvenance":"sysimport:crosswalk:entityregistry","trust":"0.900"},"title":null,"websiteurl":"http://www.uis.no/frontpage/","pid":[{"value":"0000000122999255","typeCode":"ISNI","typeLabel":"International Standard Name Identifier"},{"value":"1518722","typeCode":"OrgRef","typeLabel":"OrgRef"},{"value":"Q498401","typeCode":"Wikidata","typeLabel":"Wikidata"},{"value":"https://ror.org/02qte9q33","typeCode":"ROR","typeLabel":"ROR"},{"value":"Q498401","typeCode":"wikidata","typeLabel":"wikidata"},{"value":"92008406","typeCode":"mag_id","typeLabel":"Microsoft Academic Graph Identifier"},{"value":"100014513","typeCode":"fundref","typeLabel":"fundref"},{"value":"998023689","typeCode":"PIC","typeLabel":"Participant Identification Code"},{"value":"100014513","typeCode":"FundRef","typeLabel":"FundRef"},{"value":"grid.18883.3a","typeCode":"GRID","typeLabel":"GRID"},{"value":"grid.18883.3a","typeCode":"GRID","typeLabel":"GRID"}],"collectedfrom":[{"dsId":"openaire____::0362fcdb3076765d9c0041ad331553e8","dsName":"OpenOrgs Database"}],"author":null,"description":null,"dateofacceptance":null,"publisher":null,"codeRepositoryUrl":null,"resulttype":null,"instances":null,"officialname":null,"datasourcetype":null,"datasourcetypeui":null,"openairecompatibility":null,"legalname":"University of Stavanger","legalshortname":"UiS","country":{"code":"NO","label":"Norway"},"projectTitle":null,"code":null,"acronym":null,"contracttype":null,"funding":null,"validationDate":null,"startDate":null,"endDate":null,"givenName":null,"familyName":null,"personRoleInProject":null,"declaredAffiliation":null,"affiliationsTimeline":null}]},{"id":"corda__h2020::0006906d550cb9c20019f796fc0b5c10","code":"674806","acronym":"CESEAND InnoAses2","title":"Enhance innovation management capacities in Andalusian SMEs. 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Within this context, the role the new Community instruments have assigned to the Enterprise Europe Network, as a European-wide network of entities integrated into regional innovation systems, is that of being the lever and driving force for innovation management capacities in SMEs and, in the near future, as the organisation directly responsible for the provision of advanced services.\n\nInnovation properly combined with cooperation and internationalisation, is the only path along which SMEs can improve their competitiveness in a globalised world undergoing an industrial crisis.\n\nTherefore, our main objective is to contribute to smart growth in Andalusia, through the provision of services enhancing the innovation management capacities of Andalusian SMEs. According to this call, these are the Project's Objectives expected to be attained through this project's development and implementation:\n\n• To enhance the innovation capacities of SMEs in Andalusia in order to make them more competitive through the provision of advanced services.\n• To drive forward non-technological catalysts for innovation in SMEs.\n• To develop on behalf of the entities which comprise the Enterprise Europe Network new ways and tools to provide services to SMEs that contribute to enhancing their competitive capacities.\n• To provide support to beneficiaries of SME Instrument, accompanying them in their transition through Phases 1 and 2.\n• To identify future potential applicants to successfully take part in SME Instrument.\n• To develop methodologies that can be enhanced through their integration into the Andalusian Innovation 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This will represent the first ever general-purpose, end-to-end, fully neuromorphic vision sensing and processing system available for general usage.\nIn this project we will build a technology demonstrator and a detailed commercial business case for this technology, and demonstrate both its technological and commercial advantages. 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The transition between these states is slow but can be catalyzed by the activity of proline isomerases such as PIN1. Recent in vitro work suggests that PIN1 can alter the phosphorylation dynamics of the C-terminal domain (CTD) of RNA polymerase II (Pol II) by inhibiting phosphatase recognition. Given Pol II is solely responsible for transcribing all protein-coding genes and that CTD phosphorylation dictates the timing of RNA co-transcriptional processes, these observations suggest a crucial role for CTD proline isomerization in gene expression. Importantly, mutations in PIN1 are associated with cancer progression but a direct role for proline isomerization has remained understudied given the technical limitations imposed by its complex enzymology, such as the inability of differentiating CIS and TRANS isomers using Mass Spectrometry. In this project, I aim to functionally dissect the role of proline isomerization during Pol II transcription using rigorous biochemical, cellular and genomic techniques. Specifically, I will exploit new technological advances in peptide synthesis to permanently “lock” prolines in CIS or TRANS and identify novel isomer-specific interacting factors. I will systematically examine the consequences of CTD proline mutations and of rapid depletion of PIN1 in human cells, focusing on CTD-dependent co-transcriptional RNA processes such as splicing and poly-A–dependent 3’ termination. At the basic research level, my results will provide unprecedented resolution to the dynamics of Pol II phosphorylation, which underlies regulation of gene expression in multicellular organisms. Translationally, given that various cancers hijack the transcriptional programmes of the cell, this mechanistic understanding of CTD proline isomerization will better equip future clinical studies interested in the yet-to-be-characterized role of PIN1 in oncogenesis.","granted":{"currency":"EUR","totalCost":219312.0,"fundedAmount":219312.0},"h2020Programmes":null,"funding":{"funder":{"id":"ec__________::EC","shortname":"EC","name":"European Commission","jurisdiction":{"code":"EU","label":"European Union"},"pid":null},"level0":{"id":"ec__________::EC::H2020","description":"Horizon 2020 Framework Programme","name":"H2020"},"level1":{"id":"ec__________::EC::H2020::MSCA-IF-EF-ST","description":"Standard European Fellowships","name":"MSCA-IF-EF-ST"},"level2":null},"links":[{"header":{"relationType":"projectOrganization","relationClass":"hasParticipant","relatedIdentifier":"pending_org_::da60d0e93019a062bf6ebe8a44a6b4da","relatedRecordType":"organization","relationProvenance":"sysimport:crosswalk:entityregistry","trust":"0.900"},"title":null,"websiteurl":"http://www.ku.dk","pid":[{"value":"999991043","typeCode":"PIC","typeLabel":"Participant Identification Code"},{"value":"DK0001","typeCode":"OrgReg","typeLabel":"OrgReg"}],"collectedfrom":[{"dsId":"openaire____::0362fcdb3076765d9c0041ad331553e8","dsName":"OpenOrgs Database"}],"author":null,"description":null,"dateofacceptance":null,"publisher":null,"codeRepositoryUrl":null,"resulttype":null,"instances":null,"officialname":null,"datasourcetype":null,"datasourcetypeui":null,"openairecompatibility":null,"legalname":"KOBENHAVNS UNIVERSITET","legalshortname":"UCPH","country":{"code":"DK","label":"Denmark"},"projectTitle":null,"code":null,"acronym":null,"contracttype":null,"funding":null,"validationDate":null,"startDate":null,"endDate":null,"givenName":null,"familyName":null,"personRoleInProject":null,"declaredAffiliation":null,"affiliationsTimeline":null}]},{"id":"corda__h2020::000995071ecaa4278180d1325ba96fa3","code":"949806","acronym":"VOLUME-BIO","title":"Volumetric light-driven bioprinting capturing complex physiological shape, size and function in artificial tissues and organoids","websiteUrl":null,"startDate":"2021-01-01","endDate":"2025-12-31","callIdentifier":"ERC-2020-STG","keywords":null,"openAccessMandateForPublications":true,"openAccessMandateForDataset":false,"subjects":["ERC STARTING GRANTS"],"fundings":[{"shortName":"EC","name":"European Commission","jurisdiction":"EU","fundingStream":{"id":"EC::H2020::ERC::ERC-STG","description":"Horizon 2020 Framework Programme - European Research Council - Starting Grant"}}],"summary":"Lab-made artificial tissues and organoids promise to revolutionize medicine, tackling transplant shortage, and to innovate biological and pharmaceutical research, introducing accurate in vitro models of human physiology, as potential alternatives to animal experimentation. The functionality of living organs is intimately linked to their complex architecture, from the physicochemical properties of extracellular microenvironment, to tissue-level scale, where multiple cell populations interact in a precisely orchestrated spatial distribution. Advances in key technologies capturing this shape-function relationship in vitro can bring the long-sought goal of real tissue engineering within reach. \n\nIn VOLUME-BIO I will develop a novel multi-material volumetric bioprinting technology for the precise generation of engineered tissues and organoids exhibiting physiological functions. Inspired by optical tomography, cell-laden hydrogels are sculpted into tissue analogues within seconds, upon exposure to bio-friendly 3D visible light fields. Tuneable light patterns control the local distribution of cells and, through orthogonal photo-chemical reactions, of key factors that guide stem cell fate, namely stiffness of the extracellular matrix and morphogenetic biochemical cues. The unprecedented ability to tune independently such parameters will also permit to build 3D platforms to study how architectural complexity impacts organoid maturation. This will provide a new tool to address the so far unanswered question of how much an engineered tissue needs to mimic Nature’s template to achieve physiological functionality. \n\nBringing together my expertise in engineering, bioprinting, materials design and stem cell biology, I will first test the potential and versatility of this novel volumetric technology by building from anatomical patient-specific images functional and centimetre-scale vascularized bone and bone marrow organoid supporting physiological-like hematopoiesis.","granted":{"currency":"EUR","totalCost":1870250.0,"fundedAmount":1870250.0},"h2020Programmes":null,"funding":{"funder":{"id":"ec__________::EC","shortname":"EC","name":"European Commission","jurisdiction":{"code":"EU","label":"European Union"},"pid":null},"level0":{"id":"ec__________::EC::H2020","description":"Horizon 2020 Framework Programme","name":"H2020"},"level1":{"id":"ec__________::EC::H2020::ERC","description":"European Research 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University","country":{"code":"NL","label":"Netherlands"},"projectTitle":null,"code":null,"acronym":null,"contracttype":null,"funding":null,"validationDate":null,"startDate":null,"endDate":null,"givenName":null,"familyName":null,"personRoleInProject":null,"declaredAffiliation":null,"affiliationsTimeline":null}]},{"id":"corda__h2020::000c06cbc71a2ac6265f63fa6856f1ee","code":"101029688","acronym":"ACCESS","title":"Array of Cryogenic Calorimeters to Evaluate Spectral Shapes","websiteUrl":null,"startDate":"2022-04-02","endDate":"2025-04-01","callIdentifier":"H2020-MSCA-IF-2020","keywords":null,"openAccessMandateForPublications":true,"openAccessMandateForDataset":true,"subjects":["Individual Fellowships"],"fundings":[{"shortName":"EC","name":"European Commission","jurisdiction":"EU","fundingStream":{"id":"EC::H2020::MSCA-IF-GF","description":"Horizon 2020 Framework Programme - Global Fellowships"}}],"summary":"ACCESS aims to establish a new technique to perform precision measurements of forbidden beta-decays, whose spectral shape is a crucial benchmark for Nuclear Physics calculations and plays a pivotal role in Astroparticle Physics experiments. When fundamental conservation laws strongly suppress a beta decay, it features a high transferred momentum, as in the case of neutrinoless double-beta decay (NLDBD).  Relying on this similarity, ACCESS will provide groundbreaking insights to evaluate Nuclear Matrix Elements for NLDBD. ACCESS will operate a pilot array of four tellurium dioxide crystals as cryogenic calorimeters. Three of them will be doped with different beta emitters, while the last natural one will be used for effective background subtraction. My experience with cryogenic calorimeters based on semiconductor sensors (i.e. NTD) will be a solid basement for the project, but an essential piece of the puzzle is still missing. ACCESS requires high statistical measurements in an ultra-clean underground cryostat, available for limited time slots. A fast detector is mandatory to collect the required number of signals, keeping the background low, and avoiding the pileup due to the high counting rate. To fulfill this requirement, I will complete my training during the first two years of the action at Queen’s University. Here I will learn to build and operate bolometers based on superconductive sensors (i.e. TES), among the faster sensors used in Astroparticle Physics. I will transfer my NTD-oriented expertise to the local group, and together we will integrate these two sensors for a novel application. In the last year, I will move to GSSI, a research center of excellence recently established in Italy. Here I will perform the final measurements at LNGS (Gran Sasso National Laboratory), a world-leading underground research infrastructure of INFN. My new skills and research network will enrich the local astroparticle group, extending its research field also to Nuclear Physics.","granted":{"currency":"EUR","totalCost":255768.0,"fundedAmount":255768.0},"h2020Programmes":null,"funding":{"funder":{"id":"ec__________::EC","shortname":"EC","name":"European Commission","jurisdiction":{"code":"EU","label":"European Union"},"pid":null},"level0":{"id":"ec__________::EC::H2020","description":"Horizon 2020 Framework Programme","name":"H2020"},"level1":{"id":"ec__________::EC::H2020::MSCA-IF-GF","description":"Global Fellowships","name":"MSCA-IF-GF"},"level2":null},"links":[{"header":{"relationType":"projectOrganization","relationClass":"hasParticipant","relatedIdentifier":"openorgs____::a0404ae0f4c4b052325f6cb8adaa186c","relatedRecordType":"organization","relationProvenance":"project:organization:semrel","trust":"0.85"},"title":null,"websiteurl":"http://www.infn.it/index.php?lang=en","pid":[{"value":"grid.6045.7","typeCode":"GRID","typeLabel":"GRID"},{"value":"IT1007","typeCode":"OrgReg","typeLabel":"OrgReg"},{"value":"0000000417575281","typeCode":"ISNI","typeLabel":"International Standard Name Identifier"},{"value":"Q1674876","typeCode":"wikidata","typeLabel":"wikidata"},{"value":"501100013168","typeCode":"FundRef","typeLabel":"FundRef"},{"value":"501100004007","typeCode":"fundref","typeLabel":"fundref"},{"value":"999992789","typeCode":"PIC","typeLabel":"Participant Identification Code"},{"value":"501100004007","typeCode":"FundRef","typeLabel":"FundRef"},{"value":"501100013168","typeCode":"fundref","typeLabel":"fundref"},{"value":"7034473","typeCode":"OrgRef","typeLabel":"OrgRef"},{"value":"https://ror.org/005ta0471","typeCode":"ROR","typeLabel":"ROR"},{"value":"Q1674876","typeCode":"Wikidata","typeLabel":"Wikidata"}],"collectedfrom":[{"dsId":"openaire____::0362fcdb3076765d9c0041ad331553e8","dsName":"OpenOrgs Database"}],"author":null,"description":null,"dateofacceptance":null,"publisher":null,"codeRepositoryUrl":null,"resulttype":null,"instances":null,"officialname":null,"datasourcetype":null,"datasourcetypeui":null,"openairecompatibility":null,"legalname":"National Institute for Nuclear Physics","legalshortname":"INFN","country":{"code":"IT","label":"Italy"},"projectTitle":null,"code":null,"acronym":null,"contracttype":null,"funding":null,"validationDate":null,"startDate":null,"endDate":null,"givenName":null,"familyName":null,"personRoleInProject":null,"declaredAffiliation":null,"affiliationsTimeline":null},{"header":{"relationType":"projectOrganization","relationClass":"hasParticipant","relatedIdentifier":"openorgs____::0ad0ee66bc67ea5d1840404ff049e4e0","relatedRecordType":"organization","relationProvenance":"sysimport:crosswalk:entityregistry","trust":"0.900"},"title":null,"websiteurl":"http://www.gssi.infn.it/","pid":[{"value":"501100014350","typeCode":"fundref","typeLabel":"fundref"},{"value":"0000000460052566","typeCode":"ISNI","typeLabel":"International Standard Name Identifier"},{"value":"917519994","typeCode":"PIC","typeLabel":"Participant Identification Code"},{"value":"501100014350","typeCode":"FundRef","typeLabel":"FundRef"},{"value":"https://ror.org/043qcb444","typeCode":"ROR","typeLabel":"ROR"},{"value":"grid.466750.6","typeCode":"GRID","typeLabel":"GRID"},{"value":"Q16561696","typeCode":"Wikidata","typeLabel":"Wikidata"},{"value":"IT0249","typeCode":"OrgReg","typeLabel":"OrgReg"},{"value":"Q16561696","typeCode":"wikidata","typeLabel":"wikidata"}],"collectedfrom":[{"dsId":"openaire____::0362fcdb3076765d9c0041ad331553e8","dsName":"OpenOrgs Database"}],"author":null,"description":null,"dateofacceptance":null,"publisher":null,"codeRepositoryUrl":null,"resulttype":null,"instances":null,"officialname":null,"datasourcetype":null,"datasourcetypeui":null,"openairecompatibility":null,"legalname":"Gran Sasso Science Institute","legalshortname":"GSSI","country":{"code":"IT","label":"Italy"},"projectTitle":null,"code":null,"acronym":null,"contracttype":null,"funding":null,"validationDate":null,"startDate":null,"endDate":null,"givenName":null,"familyName":null,"personRoleInProject":null,"declaredAffiliation":null,"affiliationsTimeline":null}]}]}